Protein: CHK1
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)

Gene: CHK1, CHEK1
Organism: Homo sapiens
Interactions: 186
UniProt ID: O14757

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000785 - chromatin
GO:0000794 - condensed nuclear chromosome
GO:0001833 - inner cell mass cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154138

MPIP3
M-phase inducer phosphatase 3

17

3

Small-scale

0.988

High

154136

MPIP1
M-phase inducer phosphatase 1

9

3

Small-scale

0.973

High

154193

CDC37
Hsp90 co-chaperone Cdc37

3

1

High-throughput

0.871

High

154095

CHK1
Serine/threonine-protein kinase Chk1

3

17

Small-scale

0.865

High

154117

HS90A
Heat shock protein HSP 90-alpha

3

3

Small-scale

0.834

High

154192

DDB1
DNA damage-binding protein 1

4

0

Small-scale

0.828

High

154240

RGAP1
Rac GTPase-activating protein 1

2

1

High-throughput

0.811

High

154237

CLPB
Mitochondrial disaggregase

3

0

High-throughput

0.803

High

154164

CSK2B
Casein kinase II subunit beta

2

0

Small-scale

0.795

High

154218

NEK9
Serine/threonine-protein kinase Nek9

2

12

Small-scale

0.789

High

154118

HS90B
Heat shock protein HSP 90-beta

2

3

Small-scale

0.776

High

154165

CSK21
Casein kinase II subunit alpha

2

6

Small-scale

0.768

High

154243

CLSPN
Claspin

12

2

Small-scale

0.761

High

154181

ATR
Serine/threonine-protein kinase ATR

10

4

Small-scale

0.752

High

154137

MPIP2
M-phase inducer phosphatase 2

1

3

Small-scale

0.747

High

154250

LATS2
Serine/threonine-protein kinase LATS2

2

0

Small-scale

0.738

High

154102

CC14B
Dual specificity protein phosphatase CDC14B

1

3

Small-scale

0.724

High

154157

RD23A
UV excision repair protein RAD23 homolog A

1

2

Small-scale

0.724

High

154183

CUL1
Cullin-1

6

2

Small-scale

0.721

High

154096

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

Small-scale

0.708

High

154227

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

6

0

Small-scale

0.699

High

154113

KPCB
Protein kinase C beta type

2

0

High-throughput

0.699

High

154110

P53
Cellular tumor antigen p53

6

0

Small-scale

0.695

High

154115

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.691

High

154162

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.691

High

154161

RHOB
Rho-related GTP-binding protein RhoB

1

0

Small-scale

0.687

High

154260

DBF4A
Protein DBF4 homolog A

1

0

Small-scale

0.687

High

154184

CUL4A
Cullin-4A

4

2

Small-scale

0.676

High

154146

BRCA1
Breast cancer type 1 susceptibility protein

3

2

Small-scale

0.660

High

154103

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

0

High-throughput

0.656

High

154122

RAP2A
Ras-related protein Rap-2a

1

0

High-throughput

0.656

High

154130

VAV
Proto-oncogene vav

1

0

High-throughput

0.656

High

154178

SNTB2
Beta-2-syntrophin

1

0

High-throughput

0.656

High

154215

ZBT34
Zinc finger and BTB domain-containing protein 34

1

0

High-throughput

0.656

High

154121

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.647

High

154175

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

13

Small-scale

0.647

High

154238

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

20

Small-scale

0.647

High

154265

TLK1
Serine/threonine-protein kinase tousled-like 1

1

10

Small-scale

0.647

High

154160

1433G
14-3-3 protein gamma

2

9

Small-scale

0.639

High

154190

TCAL1
Transcription elongation factor A protein-like 1

3

0

High-throughput

0.638

High

154236

B2L14
Apoptosis facilitator Bcl-2-like protein 14

3

0

High-throughput

0.638

High

154144

FUS
RNA-binding protein FUS

1

0

High-throughput

0.631

High

154253

DTL
Denticleless protein homolog

2

1

Small-scale

0.629

High

154128

CATE
Cathepsin E

2

1

High-throughput

0.628

High

154171

1433F
14-3-3 protein eta

2

8

High-throughput

0.628

High

154220

DNJB3
DnaJ homolog subfamily B member 3

1

1

High-throughput

0.618

High

154131

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.618

High

154211

KSR1
Kinase suppressor of Ras 1

1

2

High-throughput

0.618

High

154177

ATM
Serine-protein kinase ATM

2

4

Small-scale

0.617

High

154172

RAD51
DNA repair protein RAD51 homolog 1

2

1

Small-scale

0.612

High

154139

1433B
14-3-3 protein beta/alpha

2

8

Small-scale

0.611

High

154098

MDM4
Protein Mdm4

2

0

Small-scale

0.606

High

154169

CNTN2
Contactin-2

1

0

Small-scale

0.606

High

154099

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.602

High

154188

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.602

High

154194

ERC6L
DNA excision repair protein ERCC-6-like

2

0

High-throughput

0.602

High

154208

DAA11
Dynein axonemal assembly factor 11

2

0

High-throughput

0.602

High

154232

NAT9
Alpha/beta-tubulin-N-acetyltransferase 9

2

0

High-throughput

0.602

High

154267

FZR1
Fizzy-related protein homolog

2

0

Small-scale

0.598

High

154245

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

Small-scale

0.598

High

154145

ZEB1
Zinc finger E-box-binding homeobox 1

1

0

Small-scale

0.586

High

154147

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.586

High

154148

CCNF
Cyclin-F

1

0

High-throughput

0.586

High

154203

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.586

High

154242

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.586

High

154248

KI13B
Kinesin-like protein KIF13B

1

0

High-throughput

0.586

High

154264

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.586

High

154266

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.586

High

154197

ARH
Low density lipoprotein receptor adapter protein 1

2

0

High-throughput

0.585

High

154163

1433Z
14-3-3 protein zeta/delta

2

9

Small-scale

0.584

High

154168

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

Small-scale

0.578

High

154258

HDAC6
Histone deacetylase 6

1

1

Small-scale

0.578

High

154167

PRKDC
DNA-dependent protein kinase catalytic subunit

2

4

Small-scale

0.571

High

154114

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.561

High

154143

MCM7
DNA replication licensing factor MCM7

1

4

Small-scale

0.561

High

154152

MCM2
DNA replication licensing factor MCM2

1

5

Small-scale

0.561

High

154187

MCM6
DNA replication licensing factor MCM6

1

5

Small-scale

0.561

High

154206

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.561

High

154134

DNMT1
DNA

2

0

Small-scale

0.559

High

154186

BTG3
Protein BTG3

2

0

Small-scale

0.559

High

154274

SNX11
Sorting nexin-11

2

1

High-throughput

0.558

High

154156

ATX3
Ataxin-3

1

0

Small-scale

0.554

High

154233

TRAF4
TNF receptor-associated factor 4

1

0

Small-scale

0.554

High

154276

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.554

High

154180

SQSTM
Sequestosome-1

1

0

High-throughput

0.546

High

154116

NPM
Nucleophosmin

1

0

Small-scale

0.537

High

70750

VWC2L
von Willebrand factor C domain-containing protein 2-like

1

1

High-throughput

0.536

High

154119

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.536

High

154135

1433T
14-3-3 protein theta

1

8

High-throughput

0.536

High

154224

NELL1
Protein kinase C-binding protein NELL1

1

1

High-throughput

0.536

High

154231

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

154254

RN181
E3 ubiquitin-protein ligase RNF181

1

2

High-throughput

0.536

High

154257

RBX2
RING-box protein 2

1

2

High-throughput

0.536

High

154255

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.517

High

154100

RNF13
E3 ubiquitin-protein ligase RNF13

1

0

High-throughput

0.513

High

154104

TOM1
Target of Myb1 membrane trafficking protein

1

0

High-throughput

0.513

High

154150

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

154182

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

154200

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

154201

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.513

High

154210

UN5CL
UNC5C-like protein

1

0

High-throughput

0.513

High

154214

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

154216

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.513

High

154222

H1X
Histone H1.10

1

0

High-throughput

0.513

High

154225

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

154261

FBLN5
Fibulin-5

1

0

High-throughput

0.513

High

154275

WNT6
Protein Wnt-6

1

0

High-throughput

0.513

High

154132

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

Small-scale

0.501

High

154170

TF65
Transcription factor p65

1

3

Small-scale

0.501

High

154223

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

Small-scale

0.501

High

154259

SAE2
SUMO-activating enzyme subunit 2

1

2

Small-scale

0.501

High

154263

ERRFI
ERBB receptor feedback inhibitor 1

1

2

Small-scale

0.501

High

122361

MEN1
Menin

1

0

Small-scale

0.493

High

154268

TIM
Protein timeless homolog

1

0

Small-scale

0.493

High

154097

XPO1
Exportin-1

1

0

Small-scale

0.480

High

154111

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

154123

TAU
Microtubule-associated protein tau

1

0

Small-scale

0.480

High

154153

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.480

High

154173

B2CL1
Bcl-2-like protein 1

1

0

Small-scale

0.480

High

154174

TP53B
TP53-binding protein 1

1

0

Small-scale

0.480

High

154191

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

Small-scale

0.480

High

154217

MCPH1
Microcephalin

1

0

Small-scale

0.480

High

154226

BAD
Bcl2-associated agonist of cell death

1

0

Small-scale

0.480

High

154234

FACD2
Fanconi anemia group D2 protein

1

0

Small-scale

0.480

High

154244

FANCE
Fanconi anemia group E protein

1

0

Small-scale

0.480

High

154246

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

Small-scale

0.480

High

154251

AATF
Protein AATF

1

0

Small-scale

0.480

High

154106

CDC45
Cell division control protein 45 homolog

1

1

Small-scale

0.479

High

154109

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

3

High-throughput

0.479

High

154124

PCNA
Proliferating cell nuclear antigen

1

3

Small-scale

0.479

High

154126

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

154127

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

154133

MCM3
DNA replication licensing factor MCM3

1

5

Small-scale

0.479

High

154140

1433S
14-3-3 protein sigma

1

9

Small-scale

0.479

High

154141

MCM4
DNA replication licensing factor MCM4

1

4

Small-scale

0.479

High

154142

MCM5
DNA replication licensing factor MCM5

1

4

Small-scale

0.479

High

154149

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.479

High

154154

MSH6
DNA mismatch repair protein Msh6

1

1

Small-scale

0.479

High

154158

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

154159

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

154166

H31
Histone H3.1

1

2

Small-scale

0.479

High

154176

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.479

High

154179

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

3

High-throughput

0.479

High

154202

XAF1
XIAP-associated factor 1

1

1

Small-scale

0.479

High

154239

BRD8
Bromodomain-containing protein 8

1

1

High-throughput

0.479

High

154256

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.479

High

154271

FBW1A
F-box/WD repeat-containing protein 1A

1

1

Small-scale

0.479

High

154101

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

154105

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

154107

GGYF1
GRB10-interacting GYF protein 1

1

0

High-throughput

0.458

High

154120

DPOLA
DNA polymerase alpha catalytic subunit

1

0

Small-scale

0.458

High

154129

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

Small-scale

0.458

High

154155

BLM
RecQ-like DNA helicase BLM

1

0

Small-scale

0.458

High

154185

FHL1
Four and a half LIM domains protein 1

1

0

Small-scale

0.458

High

154189

PSF1
DNA replication complex GINS protein PSF1

1

0

Small-scale

0.458

High

154196

SETMR
Histone-lysine N-methyltransferase SETMAR

1

0

Small-scale

0.458

High

154199

SPD2A
SH3 and PX domain-containing protein 2A

1

0

High-throughput

0.458

High

154205

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

154207

GLCI1
Glucocorticoid-induced transcript 1 protein

1

0

High-throughput

0.458

High

154209

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

0

Small-scale

0.458

High

154212

MILK2
MICAL-like protein 2

1

0

High-throughput

0.458

High

154219

DEN1A
DENN domain-containing protein 1A

1

0

High-throughput

0.458

High

154221

DGCR8
Microprocessor complex subunit DGCR8

1

0

Small-scale

0.458

High

154230

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

Small-scale

0.458

High

154235

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

154249

FBX6
F-box only protein 6

1

0

Small-scale

0.458

High

154252

MTMR4
Myotubularin-related protein 4

1

0

High-throughput

0.458

High

154269

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.458

High

154270

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

154272

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

154108

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

154112

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

154213

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.426

High

154151

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

118108

HAX1
HCLS1-associated protein X-1

3

0

High-throughput

0.347

High

154262

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

0

High-throughput

0.347

High

154195

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

3

0

High-throughput

0.345

High

154247

MEPE
Matrix extracellular phosphoglycoprotein

1

0

Small-scale

0.288

High

154241

PIGM
GPI mannosyltransferase 1

1

0

High-throughput

0.282

High

154198

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

154204

MTSS2
Protein MTSS 2

1

0

High-throughput

0.279

Low

154228

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.279

Low

154125

CADH1
Cadherin-1

1

0

Small-scale

0.261

Low

154229

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.249

Low

154273

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024