HitPredict

Interactor 1: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Interactor 2: TAB2 (Q9NYJ8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
Gene: TAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21512573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 493 Hs			1 693
+	Hs
		1223392 TRI22_HUMAN (1-493): 8.67e-130: 387: 50.98		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		537101 TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Mm
		548987 TR30A_MOUSE (1-493): 6.2e-115: 349: 44.49		TAB2_MOUSE (1-693): 7.87e-108: 344: 94.66
+	Hs
		135043 TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65		TAB2_HUMAN (1-693): 1.25e-111: 354: 100.00
+	Hs
		1234340 TRIM5_HUMAN (1-493): 3.88e-147: 432: 100.00		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		536926 TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Mm
		548982 TR30A_MOUSE (1-493): 6.2e-115: 349: 44.49		TAB3_MOUSE (1-692): 2.76e-71: 247: 28.96
+	Hs
		135034 TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65		TAB3_HUMAN (1-692): 2.31e-70: 245: 29.77
+	Hs
		537122 TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21		MAGL2_HUMAN (37-544): 1.37e-09: 63.6: 8.02
+	Hs
		257667 TRI41_HUMAN (1-43): 1.74e-10: 65.4: 39.54		ANR17_HUMAN (117-519): 7.6e-10: 64.7: 11.54