HitPredict

Interactor 1: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1298 Hs			1 258
+	Hs
		146646 AMRA1_HUMAN (1-1298): 0: 1603: 100.00		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		147446 AMRA1_HUMAN (1-1298): 0: 1603: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		147558 AMRA1_HUMAN (1-1298): 0: 1603: 100.00		SOCS6_HUMAN (46-256): 4.63e-45: 160: 25.69
+	Hs
		181893 AMRA1_HUMAN (1-1298): 0: 1603: 100.00		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Hs
		412300 SNR40_HUMAN (45-329): 6.16e-55: 197: 11.75		FYN_HUMAN (39-248): 8.37e-42: 151: 13.06
+	Hs
		181906 WSB1_HUMAN (57-256): 4.52e-15: 81.3: 13.51		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Hs
		986007 FBXW7_HUMAN (164-329): 5.74e-18: 91.8: 9.58		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46