HitPredict

Interactor 1: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Interactor 2: WNK1 (Q9H4A3)
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)
Gene: WNK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	20936779
Identification Methods	two hybrid pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 2382
+	Hs
		1299635 NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20		WNK1_HUMAN (1-2382): 0: 877: 100.00
+	Mm
		93269 E9PXB7_MOUSE (129-395): 7.76e-23: 102: 12.68		WNK1_MOUSE (1-2382): 0: 804: 82.86
+	Hs
		1299971 WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00		NEK1_HUMAN (218-1352): 1.24e-125: 432: 13.77
+	Hs
		808568 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		AAPK1_HUMAN (195-737): 1.29e-123: 404: 16.40
+	Hs
		1336112 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		TNIK_HUMAN (198-1222): 4.7e-123: 427: 13.42
+	Hs
		1220095 KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88		TNIK_HUMAN (198-1222): 4.7e-123: 427: 13.42
+	Mm
		949429 MAGI2_MOUSE (3-213): 3.41e-35: 140: 18.18		TNIK_MOUSE (198-1222): 1.32e-131: 451: 13.65
+	Hs
		1356405 WWC3_HUMAN (119-258): 4.68e-41: 156: 18.57		TNIK_HUMAN (198-1222): 4.7e-123: 427: 13.42
+	Mm
		949373 NED4L_MOUSE (129-395): 4.63e-24: 106: 11.96		TNIK_MOUSE (198-1222): 1.32e-131: 451: 13.65
+	Mm
		93268 E9PXB7_MOUSE (129-395): 7.76e-23: 102: 12.68		TNIK_MOUSE (198-1222): 1.32e-131: 451: 13.65
+	Mm
		808345 NEDD4_MOUSE (129-328): 8.42e-21: 96.6: 10.44		TNIK_MOUSE (198-1222): 1.32e-131: 451: 13.65
+	Sc
		419888 RSP5_YEAST (60-356): 4.36e-33: 133: 13.24		SNF1_YEAST (221-671): 1.23e-123: 407: 21.96
+	Hs
		808315 NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00		TNIK_HUMAN (198-1222): 4.7e-123: 427: 13.42
+	Hs
		681731 NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	Hs
		808324 NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00		AKT3_HUMAN (163-539): 2.39e-123: 400: 18.65
+	Hs
		1039182 WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09		KCC2D_HUMAN (219-633): 6.74e-126: 408: 19.91
+	Hs
		681988 NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	Hs
		1299620 NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20		WNK3_HUMAN (1397-2378): 2.71e-57: 222: 18.10
+	Hs
		1294939 NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20		WNK4_HUMAN (1724-2142): 2.06e-16: 88.5: 22.20
+	Hs
		1233533 NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20		MINK1_HUMAN (604-1227): 3.59e-09: 64.8: 11.68