Protein: MIA40
Mitochondrial intermembrane space import and assembly protein 40 (Mitochondrial import inner membrane translocase TIM40)

Gene: MIA40
Organism: Saccharomyces cerevisiae S288C
Interactions: 110
UniProt ID: P36046

Gene Ontology (top 5):
GO:0003756 - protein disulfide isomerase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

699367

ERV1
Mitochondrial FAD-linked sulfhydryl oxidase ERV1

17

1

Small-scale

0.763

High

267943

TIM9
Mitochondrial import inner membrane translocase subunit TIM9

11

0

Small-scale

0.722

High

780124

TIM10
Mitochondrial import inner membrane translocase subunit TIM10

5

2

Small-scale

0.721

High

780120

TIM13
Mitochondrial import inner membrane translocase subunit TIM13

4

2

Small-scale

0.680

High

780136

COX17
Cytochrome c oxidase copper chaperone

5

0

Small-scale

0.674

High

780121

ATP23
Mitochondrial inner membrane protease ATP23

2

0

Small-scale

0.607

High

780090

MIA40
Mitochondrial intermembrane space import and assembly protein 40

2

1

Small-scale

0.595

High

780111

CCS1
Superoxide dismutase 1 copper chaperone

2

1

Small-scale

0.595

High

780091

COXM1
COX assembly mitochondrial protein

2

0

Small-scale

0.592

High

661785

TOM40
Mitochondrial import receptor subunit TOM40

2

0

Small-scale

0.592

High

745545

TIM12
Mitochondrial import inner membrane translocase subunit TIM12

2

2

Small-scale

0.585

High

523591

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.571

High

526389

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.571

High

780123

TIM8
Mitochondrial import inner membrane translocase subunit TIM8

2

1

Small-scale

0.571

High

780093

MIC60
MICOS complex subunit MIC60

2

0

High-throughput

0.559

High

544447

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.558

High

780141

COX19
Cytochrome c oxidase assembly protein COX19

2

0

Small-scale

0.547

High

780092

HOT13
Helper of Tim protein 13

1

0

Small-scale

0.537

High

780118

TOM22
Mitochondrial import receptor subunit TOM22

2

0

Small-scale

0.528

High

780114

GPX3
Glutathione peroxidase-like peroxiredoxin HYR1

1

0

Small-scale

0.505

High

357700

CYC1
Cytochrome c isoform 1

1

1

Small-scale

0.501

High

357730

CYC7
Cytochrome c isoform 2

1

1

Small-scale

0.501

High

656422

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.480

High

780119

TIM21
Mitochondrial import inner membrane translocase subunit TIM21

1

0

Small-scale

0.480

High

780130

AIM32
Altered inheritance of mitochondria protein 32

1

0

Small-scale

0.480

High

510381

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.479

High

780128

MIX17
Mitochondrial intermembrane space cysteine motif-containing protein MIX17

1

2

Small-scale

0.479

High

780137

TIM22
Mitochondrial import inner membrane translocase subunit TIM22

1

1

Small-scale

0.479

High

399816

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

453133

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

Small-scale

0.458

High

780104

TIM17
Mitochondrial import inner membrane translocase subunit TIM17

1

0

Small-scale

0.458

High

780109

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

780125

PT191
Mitochondrial protein PET191

1

0

Small-scale

0.458

High

780135

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

358011

CYB2
L-lactate dehydrogenase

1

1

Small-scale

0.445

High

452010

TOM70
Mitochondrial import receptor subunit TOM70

1

2

Small-scale

0.445

High

456386

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.445

High

613557

ADT2
ADP,ATP carrier protein 2

1

3

High-throughput

0.445

High

661610

MPCP
Mitochondrial phosphate carrier protein

1

3

High-throughput

0.445

High

734363

OAC1
Mitochondrial oxaloacetate transport protein

1

4

High-throughput

0.445

High

741338

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

752116

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

763418

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.445

High

780101

HXT6
High-affinity hexose transporter HXT6

1

3

High-throughput

0.445

High

780102

HXT7
High-affinity hexose transporter HXT7

1

3

High-throughput

0.445

High

780103

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

780107

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.445

High

780113

FLX1
Mitochondrial FAD carrier protein FLX1

1

4

High-throughput

0.445

High

706771

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

780094

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

1

High-throughput

0.437

High

360965

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

Small-scale

0.426

High

361432

SODC
Superoxide dismutase [Cu-Zn]

1

0

Small-scale

0.426

High

366997

ATPB
ATP synthase subunit beta, mitochondrial

1

0

High-throughput

0.426

High

458556

SEC4
Ras-related protein SEC4

1

0

High-throughput

0.426

High

569395

DPM1
Dolichol-phosphate mannosyltransferase

1

0

High-throughput

0.426

High

721095

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

0

High-throughput

0.426

High

723171

ATP7
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.426

High

743379

TOR2
Serine/threonine-protein kinase TOR2

1

0

High-throughput

0.426

High

751064

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

High-throughput

0.426

High

779040

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.426

High

780095

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.426

High

780098

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.426

High

780106

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.426

High

780112

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

0

High-throughput

0.426

High

780134

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

Small-scale

0.426

High

150092

YA11B
Truncated transposon Ty1-A Gag-Pol polyprotein

1

7

High-throughput

0.407

High

386670

TBB
Tubulin beta chain

1

2

High-throughput

0.407

High

486130

TBA1
Tubulin alpha-1 chain

1

3

High-throughput

0.407

High

486448

TBA3
Tubulin alpha-3 chain

1

3

High-throughput

0.407

High

504568

YD14B
Transposon Ty1-DR5 Gag-Pol polyprotein

1

7

High-throughput

0.407

High

504575

YD15B
Transposon Ty1-DR6 Gag-Pol polyprotein

1

7

High-throughput

0.407

High

597433

EF3A
Elongation factor 3A

1

1

High-throughput

0.407

High

671357

PHO84
Inorganic phosphate transporter PHO84

1

4

High-throughput

0.407

High

678920

FIG2
Factor-induced gene 2 protein

1

2

High-throughput

0.407

High

737260

HXT3
Low-affinity glucose transporter HXT3

1

3

High-throughput

0.407

High

737286

HXT4
Low-affinity glucose transporter HXT4

1

3

High-throughput

0.407

High

780105

BDH1
(R,R)-butanediol dehydrogenase

1

1

High-throughput

0.407

High

780110

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.407

High

780122

EF3B
Elongation factor 3B

1

1

High-throughput

0.407

High

780126

YE11B
Transposon Ty1-ER1 Gag-Pol polyprotein

1

7

High-throughput

0.407

High

780127

YE12B
Transposon Ty1-ER2 Gag-Pol polyprotein

1

7

High-throughput

0.407

High

780129

YD11B
Transposon Ty1-DR1 Gag-Pol polyprotein

1

7

High-throughput

0.407

High

780142

YD12B
Transposon Ty1-DR3 Gag-Pol polyprotein

1

7

High-throughput

0.407

High

633457

PP11
Serine/threonine-protein phosphatase PP1-1

3

0

High-throughput

0.335

High

780117

SA155
SIT4-associating protein SAP155

2

0

High-throughput

0.298

High

675903

MAS5
Mitochondrial protein import protein MAS5

2

0

High-throughput

0.288

High

358186

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.279

Low

780108

IMB4
Importin subunit beta-4

1

0

High-throughput

0.279

Low

757368

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.269

Low

780100

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.269

Low

780096

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

780131

POC1
Proteasome chaperone 1

1

0

High-throughput

0.249

Low

780139

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

452498

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.232

Low

536106

ARF1
ADP-ribosylation factor 1

1

0

High-throughput

0.232

Low

618858

GAP1
General amino-acid permease GAP1

1

0

High-throughput

0.232

Low

636299

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.232

Low

644752

CLH
Clathrin heavy chain

1

0

High-throughput

0.232

Low

668453

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.232

Low

698136

KRE2
Glycolipid 2-alpha-mannosyltransferase

1

0

High-throughput

0.232

Low

743329

FIMB
Fimbrin

1

0

High-throughput

0.232

Low

780097

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.232

Low

780099

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.232

Low

780115

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.232

Low

780116

SPR3
Sporulation-regulated protein 3

1

0

High-throughput

0.232

Low

780132

SUE1
Protein SUE1, mitochondrial

1

0

Small-scale

0.232

Low

780133

PUN1
Protein PUN1

1

0

High-throughput

0.232

Low

780138

GPR1
G protein-coupled receptor GPR1

1

0

High-throughput

0.232

Low

780140

NOP58
Nucleolar protein 58

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025