HitPredict

Interactor 1: RNF38 (Q9H0F5)
E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38)
Gene: RNF38

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 515 Hs			1 147
+	Hs
		849443 RNF38_HUMAN (1-515): 5.32e-114: 348: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919859 RNF38_HUMAN (1-515): 5.32e-114: 348: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895909 RNF38_HUMAN (1-515): 5.32e-114: 348: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		896541 RNF38_HUMAN (1-515): 5.32e-114: 348: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		1169203 RN111_HUMAN (2-508): 6.5e-50: 186: 17.74		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		196372 PJA2_HUMAN (59-514): 6.53e-51: 186: 14.62		UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00
+	Hs
		196282 PJA2_HUMAN (59-514): 6.53e-51: 186: 14.62		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		849348 RN111_HUMAN (2-508): 6.5e-50: 186: 17.74		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	At
		96605 F4IQ07_ARATH (11-510): 2.09e-51: 186: 13.16		UBC9_ARATH (1-147): 1.26e-82: 241: 80.27
+	Hs
		196294 PJA2_HUMAN (59-514): 6.53e-51: 186: 14.62		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		919758 RN111_HUMAN (2-508): 6.5e-50: 186: 17.74		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		196289 PJA2_HUMAN (59-514): 6.53e-51: 186: 14.62		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		895821 RN111_HUMAN (2-508): 6.5e-50: 186: 17.74		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	At
		96610 F4IQ07_ARATH (11-510): 2.09e-51: 186: 13.16		UBC29_ARATH (1-147): 3.11e-79: 232: 76.87
+	At
		715138 Q8VYL4_ARATH (11-510): 3.76e-46: 171: 13.16		UBC9_ARATH (1-147): 1.26e-82: 241: 80.27
+	Hs
		1169179 RN111_HUMAN (2-508): 6.5e-50: 186: 17.74		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1169175 RN111_HUMAN (2-508): 6.5e-50: 186: 17.74		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851828 RN111_HUMAN (2-508): 6.5e-50: 186: 17.74		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		196290 PJA2_HUMAN (59-514): 6.53e-51: 186: 14.62		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Hs
		896473 RN111_HUMAN (2-508): 6.5e-50: 186: 17.74		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53