HitPredict

Interactor 1: IKZF5 (Q9H5V7)
Zinc finger protein Pegasus (Ikaros family zinc finger protein 5)
Gene: IKZF5

Interactor 2: IKZF2 (Q9UKS7)
Zinc finger protein Helios (Ikaros family zinc finger protein 2)
Gene: IKZF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 419 Hs			1 526
+	Hs
		1033755 IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19		IKZF2_HUMAN (1-526): 0: 696: 100.00
+	Hs
		563279 ZNF7_HUMAN (7-416): 1.18e-178: 516: 16.43		ZNF16_HUMAN (16-525): 0: 533: 17.04
+	Hs
		1356563 IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22		IKZF2_HUMAN (1-526): 0: 696: 100.00
+	Hs
		1329653 IKZF5_HUMAN (1-419): 0: 536: 100.00		IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22
+	Hs
		1033733 IKZF5_HUMAN (1-419): 0: 536: 100.00		IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20
+	Hs
		1356562 IKZF2_HUMAN (10-419): 1.11e-99: 308: 23.19		IKZF2_HUMAN (1-526): 0: 696: 100.00
+	Hs
		1332095 IKZF5_HUMAN (1-419): 0: 536: 100.00		IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52
+	Hs
		1033731 IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19		IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22
+	Hs
		1033630 IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19		IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20
+	Hs
		1329658 IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22		IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22
+	Hs
		1033756 IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19		IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52
+	Hs
		1356574 IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22		IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52
+	Hs
		563270 ZN708_HUMAN (2-395): 4.41e-160: 464: 15.06		ZKSC8_HUMAN (71-299): 1.33e-78: 259: 22.08
+	Hs
		1332084 IKZF5_HUMAN (1-419): 0: 536: 100.00		IKZF5_HUMAN (87-526): 1.55e-28: 119: 25.44
+	Hs
		64162 ZN726_HUMAN (1-301): 5.97e-135: 402: 17.95		ZN430_HUMAN (120-504): 7.71e-47: 173: 17.42