HitPredict

Interactor 1: PELI2 (Q9HAT8)
E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2)
Gene: PELI2

Interactor 2: IRAK4 (Q9NWZ3)
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)
Gene: IRAK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	12860405, 17675297
Identification Methods	affinity chromatography technology, two hybrid, enzymatic study, anti tag coimmunoprecipitation, coimmunoprecipitation, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 420 Hs			1 460
+	Hs
		1291025 PELI1_HUMAN (1-420): 0: 796: 81.43		IRAK4_HUMAN (1-460): 7.17e-177: 505: 100.00
+	Hs
		1231624 PELI3_HUMAN (3-420): 0: 698: 67.27		IRAK4_HUMAN (1-460): 7.17e-177: 505: 100.00