HitPredict

Interactor 1: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Interactor 2: PKHA6 (Q9Y2H5)
Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Gene: PLEKHA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PH
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1116 Hs			1 1048
+	Hs
		1334839 PKHA5_HUMAN (1-1116): 0: 609: 100.00		PKHA5_HUMAN (1-1012): 2.52e-108: 365: 29.73
+	Hs
		1331328 PKHA5_HUMAN (1-1116): 0: 609: 100.00		PKHA4_HUMAN (7-356): 9.25e-41: 164: 26.52
+	Hs
		1153251 PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32		PKHA7_HUMAN (1-953): 1.72e-90: 315: 23.76
+	Hs
		1300697 MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66		PKHA6_HUMAN (1-1048): 2.97e-136: 439: 100.00
+	Hs
		1153259 PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32		MPRIP_HUMAN (2-667): 4.03e-48: 188: 13.90
+	Hs
		1153383 PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32		PKHA4_HUMAN (7-356): 9.25e-41: 164: 26.52
+	Hs
		1300670 MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66		PKHA5_HUMAN (1-1012): 2.52e-108: 365: 29.73
+	Hs
		1231299 RHG24_HUMAN (171-755): 5.66e-59: 219: 13.12		DOC10_HUMAN (25-755): 4.77e-75: 274: 11.51
+	Hs
		1153341 MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66		PKHA7_HUMAN (1-953): 1.72e-90: 315: 23.76
+	Hs
		1331666 PKHA6_HUMAN (109-1116): 8.74e-73: 264: 28.52		PKHA4_HUMAN (7-356): 9.25e-41: 164: 26.52
+	Hs
		1127521 RHG22_HUMAN (139-751): 3.05e-43: 170: 15.09		DOC11_HUMAN (47-721): 9.06e-68: 251: 9.76
+	Hs
		1231269 RHG24_HUMAN (171-755): 5.66e-59: 219: 13.12		RHG24_HUMAN (60-666): 3.27e-44: 174: 12.62
+	Hs
		596403 ACAP2_HUMAN (128-692): 2.59e-47: 184: 13.38		RASA1_HUMAN (76-636): 1.95e-46: 183: 12.80
+	Hs
		1167407 MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66		MPRIP_HUMAN (2-667): 4.03e-48: 188: 13.90
+	Rn
		1378274 CNKR2_RAT (120-329): 4.34e-47: 185: 26.48		CNKR2_RAT (28-466): 2.71e-43: 173: 14.55
+	Hs
		1066128 ACAP2_HUMAN (128-692): 2.59e-47: 184: 13.38		ACAP3_HUMAN (35-313): 2.91e-39: 159: 15.63
+	Hs
		1035417 GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25		GAB1_HUMAN (57-571): 1.19e-38: 156: 13.15
+	Hs
		1331332 PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43		PKHA4_HUMAN (7-356): 9.25e-41: 164: 26.52
+	Dm
		1181488 Q7KNQ9_DROME (45-407): 4.73e-51: 199: 16.37		Q9V9Q6_DROME (60-159): 1.69e-29: 124: 25.83
+	Dm
		113976 M9PB30_DROME (75-1108): 1.56e-58: 224: 10.96		M9PB30_DROME (313-1037): 3.86e-15: 83.1: 10.38