HitPredict

Interactor 1: DDX3X (O00571)
ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)
Gene: DDX3X

Interactor 2: EIF3B (P55884)
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)
Gene: EIF3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	29395067, 18628297
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0006413 - translational initiation GO:0010494 - cytoplasmic stress granule GO:0031369 - translation initiation factor binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 662 Hs			1 814
+	Sc
		410046 DED1_YEAST (10-633): 3.96e-151: 452: 47.28		EIF3B_YEAST (139-790): 1.9e-118: 377: 29.36
+	Hs
		133956 DDX3X_HUMAN (1-662): 0: 614: 100.00		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71
+	Sc
		416035 DED1_YEAST (10-633): 3.96e-151: 452: 47.28		EIF2A_YEAST (343-705): 1.57e-86: 289: 19.95
+	Hs
		571382 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71
+	Hs
		1271679 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		NLE1_HUMAN (507-723): 2.49e-34: 139: 17.03
+	Hs
		903410 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		WDR5_HUMAN (554-729): 7.19e-35: 137: 12.71
+	Ce
		712774 GLH1_CAEEL (157-575): 1.85e-104: 336: 42.99		Q9TYV3_CAEEL (533-723): 6.39e-28: 120: 15.35