Protein: MUC1
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]

Gene: MUC1
Organism: Homo sapiens
Interactions: 169
UniProt ID: P15941

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0002039 - p53 binding
GO:0003712 - transcription coregulator activity
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

590322

BT2A2
Butyrophilin subfamily 2 member A2

2

2

High-throughput

0.783

High

590252

CTNB1
Catenin beta-1

9

2

Small-scale

0.757

High

362705

EGFR
Epidermal growth factor receptor

8

18

Small-scale

0.756

High

557066

SRC
Proto-oncogene tyrosine-protein kinase Src

3

8

Small-scale

0.692

High

590327

VPP1
V-type proton ATPase 116 kDa subunit a 1

3

2

High-throughput

0.667

High

590361

VPP2
V-type proton ATPase 116 kDa subunit a 2

3

2

High-throughput

0.667

High

590235

MUC1
Mucin-1

1

15

Small-scale

0.665

High

590260

GSK3B
Glycogen synthase kinase-3 beta

2

8

Small-scale

0.660

High

590268

GRB2
Growth factor receptor-bound protein 2

2

10

Small-scale

0.640

High

590334

MYADM
Myeloid-associated differentiation marker

3

0

High-throughput

0.636

High

362149

ABL1
Tyrosine-protein kinase ABL1

1

7

Small-scale

0.609

High

163234

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

3

High-throughput

0.606

High

328625

VAMP5
Vesicle-associated membrane protein 5

2

2

High-throughput

0.606

High

421441

A4
Amyloid-beta precursor protein

2

4

High-throughput

0.606

High

444677

CO2
Complement C2

2

1

High-throughput

0.606

High

451652

TRBM
Thrombomodulin

2

16

High-throughput

0.606

High

539455

ITAM
Integrin alpha-M

2

1

High-throughput

0.606

High

590247

AQP1
Aquaporin-1

2

2

High-throughput

0.606

High

590248

MIP
Lens fiber major intrinsic protein

2

2

High-throughput

0.606

High

590250

CD68
Macrosialin

2

1

High-throughput

0.606

High

590257

AQP2
Aquaporin-2

2

2

High-throughput

0.606

High

590263

CLD6
Claudin-6

2

1

High-throughput

0.606

High

590265

MYPR
Myelin proteolipid protein

2

1

High-throughput

0.606

High

590270

CP4F2
Cytochrome P450 4F2

2

2

High-throughput

0.606

High

590280

MALL
MAL-like protein

2

1

High-throughput

0.606

High

590285

ADIPO
Adiponectin

2

3

High-throughput

0.606

High

590304

ZDH21
Palmitoyltransferase ZDHHC21

2

2

High-throughput

0.606

High

590313

CLD19
Claudin-19

2

1

High-throughput

0.606

High

590319

O10AG
Olfactory receptor 10AG1

2

1

High-throughput

0.606

High

590323

AQP3
Aquaporin-3

2

2

High-throughput

0.606

High

590326

NINJ1
Ninjurin-1

2

1

High-throughput

0.606

High

590328

MAL2
Protein MAL2

2

1

High-throughput

0.606

High

590332

CKLF7
CKLF-like MARVEL transmembrane domain-containing protein 7

2

1

High-throughput

0.606

High

590352

NINJ2
Ninjurin-2

2

1

High-throughput

0.606

High

410586

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

17

Small-scale

0.584

High

590239

LEG3
Galectin-3

2

2

Small-scale

0.584

High

590276

SOS1
Son of sevenless homolog 1

2

2

Small-scale

0.584

High

74151

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.580

High

155435

C2C2L
Phospholipid transfer protein C2CD2L

2

0

High-throughput

0.580

High

239463

AGRB3
Adhesion G protein-coupled receptor B3

2

0

High-throughput

0.580

High

277048

ENTP3
Ectonucleoside triphosphate diphosphohydrolase 3

2

0

High-throughput

0.580

High

377847

GAST
Gastrin [Cleaved into: Gastrin-71

2

0

High-throughput

0.580

High

387506

APOA2
Apolipoprotein A-II

2

0

High-throughput

0.580

High

547961

PSPC
Surfactant protein C

2

0

High-throughput

0.580

High

590237

TMM11
Transmembrane protein 11, mitochondrial

2

0

High-throughput

0.580

High

590240

CD53
Leukocyte surface antigen CD53

2

0

High-throughput

0.580

High

590246

PPLA
Phospholamban

2

0

High-throughput

0.580

High

590256

GDNF
Glial cell line-derived neurotrophic factor

2

0

High-throughput

0.580

High

590262

EMP3
Epithelial membrane protein 3

2

0

High-throughput

0.580

High

590271

RHD
Blood group Rh(D) polypeptide

2

0

High-throughput

0.580

High

590274

CCG1
Voltage-dependent calcium channel gamma-1 subunit

2

0

High-throughput

0.580

High

590275

CXCL9
C-X-C motif chemokine 9

2

0

High-throughput

0.580

High

590277

CD47
Leukocyte surface antigen CD47

2

0

High-throughput

0.580

High

590287

NKG7
Protein NKG7

2

0

High-throughput

0.580

High

590293

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.580

High

590295

TTMP
TPA-induced transmembrane protein

2

0

High-throughput

0.580

High

590300

MFSD5
Molybdate-anion transporter

2

0

High-throughput

0.580

High

590301

BRID5
BRICHOS domain-containing protein 5

2

0

High-throughput

0.580

High

590302

PAQR6
Membrane progestin receptor delta

2

0

High-throughput

0.580

High

590305

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

0

High-throughput

0.580

High

590307

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.580

High

590316

NRAC
Nutritionally-regulated adipose and cardiac enriched protein homolog

2

0

High-throughput

0.580

High

590320

CLDN2
Claudin domain-containing protein 2

2

0

High-throughput

0.580

High

590321

SCAM5
Secretory carrier-associated membrane protein 5

2

0

High-throughput

0.580

High

590335

NEUR1
Sialidase-1

2

0

High-throughput

0.580

High

590340

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

590351

TECR
Very-long-chain enoyl-CoA reductase

2

0

High-throughput

0.580

High

590354

MARH2
E3 ubiquitin-protein ligase MARCHF2

2

0

High-throughput

0.580

High

590359

TMM98
Transmembrane protein 98

2

0

High-throughput

0.580

High

590363

SELK
Selenoprotein K

2

0

High-throughput

0.580

High

463316

LYN
Tyrosine-protein kinase Lyn

1

8

Small-scale

0.578

High

590255

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.578

High

590273

KPCD
Protein kinase C delta type

1

3

Small-scale

0.578

High

254045

CTND1
Catenin delta-1

1

7

Small-scale

0.561

High

395433

ESR1
Estrogen receptor

1

20

Small-scale

0.561

High

413134

P53
Cellular tumor antigen p53

1

6

Small-scale

0.561

High

461114

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.561

High

590238

CEBPB
CCAAT/enhancer-binding protein beta

1

8

Small-scale

0.561

High

590251

HSP74
Heat shock 70 kDa protein 4

1

5

Small-scale

0.561

High

590281

ATM
Serine-protein kinase ATM

1

5

Small-scale

0.561

High

590284

TWST1
Twist-related protein 1

1

4

Small-scale

0.561

High

590249

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

2

5

High-throughput

0.553

High

590303

ANR46
Ankyrin repeat domain-containing protein 46

2

13

High-throughput

0.553

High

590308

TM86A
Lysoplasmalogenase TMEM86A

2

1

High-throughput

0.553

High

590312

TM86B
Lysoplasmalogenase TMEM86B

2

1

High-throughput

0.553

High

590314

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

2

1

High-throughput

0.553

High

590325

B2CL2
Bcl-2-like protein 2

2

1

High-throughput

0.553

High

590329

S35B4
Nucleotide sugar transporter SLC35B4

2

1

High-throughput

0.553

High

590355

TM14C
Transmembrane protein 14C

2

1

High-throughput

0.553

High

590360

GOT1B
Vesicle transport protein GOT1B

2

1

High-throughput

0.553

High

590362

INSI2
Insulin-induced gene 2 protein

2

1

High-throughput

0.553

High

590364

TM14A
Transmembrane protein 14A

2

1

High-throughput

0.553

High

439935

LCK
Tyrosine-protein kinase Lck

1

8

Small-scale

0.536

High

590259

ZAP70
Tyrosine-protein kinase ZAP-70

1

12

Small-scale

0.536

High

590266

ACTA
Actin, aortic smooth muscle

1

13

High-throughput

0.536

High

590269

VAMP2
Vesicle-associated membrane protein 2

1

2

High-throughput

0.536

High

590291

ACTBL
Beta-actin-like protein 2

1

13

High-throughput

0.536

High

590317

AT11C
Phospholipid-transporting ATPase IG

1

2

High-throughput

0.536

High

429247

JUN
Transcription factor Jun

1

9

Small-scale

0.515

High

590258

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.513

High

590298

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.513

High

590254

NUP62
Nuclear pore glycoprotein p62

1

5

Small-scale

0.512

High

590236

H2AX
Histone H2AX

1

8

Small-scale

0.501

High

590253

BMI1
Polycomb complex protein BMI-1

1

9

Small-scale

0.501

High

590286

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.501

High

590309

GALT4
Polypeptide N-acetylgalactosaminyltransferase 4

1

1

Small-scale

0.501

High

528657

PPGB
Lysosomal protective protein

1

1

High-throughput

0.481

High

590244

CO8A2
Collagen alpha-2(VIII) chain

1

6

High-throughput

0.481

High

590272

PLP2
Proteolipid protein 2

1

1

High-throughput

0.481

High

590356

LPAR3
Lysophosphatidic acid receptor 3

1

1

High-throughput

0.481

High

133935

IPO5
Importin-5

1

1

Small-scale

0.479

High

167811

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.479

High

471975

MET
Hepatocyte growth factor receptor

1

7

Small-scale

0.479

High

577598

PLAK
Junction plakoglobin

1

3

Small-scale

0.479

High

590241

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.479

High

590242

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

17

Small-scale

0.479

High

590243

APC
Adenomatous polyposis coli protein

1

16

Small-scale

0.479

High

590245

U2AF2
Splicing factor U2AF 65 kDa subunit

1

8

Small-scale

0.479

High

590279

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

590283

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

18

Small-scale

0.479

High

590288

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.479

High

590324

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

590343

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

10

Small-scale

0.479

High

590365

NEMO
NF-kappa-B essential modulator

1

5

Small-scale

0.479

High

590278

Q08AM2
ADAM33 protein

1

4

High-throughput

0.470

High

590289

Q4VAQ0
COL8A2 protein

1

5

High-throughput

0.470

High

590292

Q59EV6
Carboxypeptidase

1

1

High-throughput

0.470

High

184003

S22A1
Solute carrier family 22 member 1

1

0

Small-scale

0.460

High

590297

RTP2
Receptor-transporting protein 2

1

0

High-throughput

0.460

High

590344

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.460

High

590267

RL11
Large ribosomal subunit protein uL5

1

0

Small-scale

0.458

High

590306

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

1

Small-scale

0.457

High

280115

SC22B
Vesicle-trafficking protein SEC22b

1

1

High-throughput

0.439

High

590341

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

4

High-throughput

0.439

High

590349

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

1

1

High-throughput

0.439

High

380733

HBD
Hemoglobin subunit delta

1

1

High-throughput

0.437

High

49621

T120B
Transmembrane protein 120B

2

0

High-throughput

0.316

High

208960

CYB5B
Cytochrome b5 type B

2

0

High-throughput

0.316

High

254268

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

2

0

High-throughput

0.316

High

328223

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

2

0

High-throughput

0.316

High

590261

LIPR1
Inactive pancreatic lipase-related protein 1

2

0

High-throughput

0.316

High

590264

EP3B
Epididymal secretory protein E3-beta

2

0

High-throughput

0.316

High

590282

TM187
Transmembrane protein 187

2

0

High-throughput

0.316

High

590290

UNC50
Protein unc-50 homolog

2

0

High-throughput

0.316

High

590294

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

590299

S35E4
Solute carrier family 35 member E4

2

0

High-throughput

0.316

High

590311

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

0

High-throughput

0.316

High

590315

SERP2
Stress-associated endoplasmic reticulum protein 2

2

0

High-throughput

0.316

High

590318

T229B
Transmembrane protein 229B

2

0

High-throughput

0.316

High

590330

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

2

0

High-throughput

0.316

High

590336

VKOR1
Vitamin K epoxide reductase complex subunit 1

2

0

High-throughput

0.316

High

590337

TM121
Transmembrane protein 121

2

0

High-throughput

0.316

High

590338

TM243
Transmembrane protein 243

2

0

High-throughput

0.316

High

590339

EMC6
ER membrane protein complex subunit 6

2

0

High-throughput

0.316

High

590342

TM6S2
Transmembrane 6 superfamily member 2

2

0

High-throughput

0.316

High

590345

ARV1
Protein ARV1

2

0

High-throughput

0.316

High

590346

HHATL
Protein-cysteine N-palmitoyltransferase HHAT-like protein

2

0

High-throughput

0.316

High

590347

GP108
Protein GPR108

2

0

High-throughput

0.316

High

590348

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

2

0

High-throughput

0.316

High

590350

S38A7
Sodium-coupled neutral amino acid transporter 7

2

0

High-throughput

0.316

High

590353

CC167
Coiled-coil domain-containing protein 167

2

0

High-throughput

0.316

High

590358

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.316

High

590296

MKS3
Meckelin

1

0

High-throughput

0.279

Low

590310

VMA12
Vacuolar ATPase assembly protein VMA12

1

0

High-throughput

0.279

Low

590333

VMA22
Vacuolar ATPase assembly protein VMA22

1

0

High-throughput

0.279

Low

590357

TM59L
Transmembrane protein 59-like

1

0

High-throughput

0.279

Low

60553

TM218
Transmembrane protein 218

1

0

High-throughput

0.251

Low

590331

YIPF6
Protein YIPF6

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025