HitPredict

Interactor 1: AGC15 (Q9LTW5)
Serine/threonine-protein kinase AGC1-5 (EC 2.7.11.1) (AGC serine/threonine-protein kinase subfamily 1 member 5)
Gene: AGC1-5

Interactor 2: PDPK1 (Q9XF67)
3-phosphoinositide-dependent protein kinase 1 (AtPDK1) (EC 2.7.11.1)
Gene: PDPK1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	16973627, 21798944
Identification Methods	pull down, in-gel kinase assay
Interaction Type	direct interaction, physical association, enzymatic reaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0016301 - kinase activity GO:0106310 - protein serine kinase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 577 At			1 491
+	At
		1247584 Q8RY37_ARATH (1-577): 3.55e-139: 423: 44.48		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		1093333 AGC17_ARATH (58-577): 1.98e-141: 422: 59.10		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		1352858 D6KL1_ARATH (71-577): 3.53e-137: 409: 49.16		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		1352414 KIPK2_ARATH (3-530): 7.2e-130: 404: 43.96		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		1337841 KIPK1_ARATH (16-530): 1.31e-127: 398: 46.24		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		1339809 Q9LUK3_ARATH (74-577): 4.37e-131: 394: 38.60		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		985500 D6KL3_ARATH (26-577): 5.23e-130: 394: 46.02		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		1322853 D6PK_ARATH (75-577): 6.88e-131: 393: 40.04		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		1107155 D6KL2_ARATH (3-577): 3.43e-128: 389: 35.61		PDPK1_ARATH (1-491): 0: 523: 100.00
+	At
		248799 PID_ARATH (104-551): 6.67e-130: 389: 43.20		PDPK1_ARATH (1-491): 0: 523: 100.00
+	Sl
		1126590 Q5I6E9_SOLLC (17-577): 1.05e-138: 420: 47.95		Q5I6E8_SOLLC (2-491): 1.13e-170: 491: 80.61
+	At
		95768 RHS3_ARATH (79-577): 3.32e-128: 386: 44.12		PDPK1_ARATH (1-491): 0: 523: 100.00
+	Mm
		554867 KPCE_MOUSE (74-577): 2.83e-123: 381: 22.22		AKT1_MOUSE (2-372): 5.65e-146: 428: 30.56
+	Hs
		566289 KPCA_HUMAN (1-576): 1.62e-124: 382: 18.82		KPCL_HUMAN (3-378): 1.27e-140: 421: 27.70
+	Hs
		623873 KPCE_HUMAN (86-577): 1.24e-123: 382: 23.15		KPCL_HUMAN (3-378): 1.27e-140: 421: 27.70
+	Hs
		182135 KPCE_HUMAN (86-577): 1.24e-123: 382: 23.15		PDPK1_HUMAN (18-491): 8.09e-142: 420: 35.39
+	Hs
		969118 KPCE_HUMAN (86-577): 1.24e-123: 382: 23.15		KS6B2_HUMAN (30-407): 3.62e-141: 416: 30.26
+	Sc
		629516 KIN82_YEAST (4-574): 7.87e-130: 398: 25.73		FPK1_YEAST (26-325): 5e-58: 207: 40.00
+	Sc
		864555 FPK1_YEAST (2-574): 1.99e-122: 384: 24.88		FPK1_YEAST (26-325): 5e-58: 207: 40.00