Protein: SHRPN
Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1)

Gene: SHRPN, SHARPIN
Organism: Homo sapiens
Interactions: 191
UniProt ID: Q9H0F6

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005829 - cytosol
GO:0007005 - mitochondrion organization
GO:0008270 - zinc ion binding
GO:0010803 - regulation of tumor necrosis factor-mediated signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1429977

SHRPN
Sharpin

3

4

Small-scale

0.847

High

1389379

RNF31
E3 ubiquitin-protein ligase RNF31

34

4

Small-scale

0.770

High

1418794

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

16

4

Small-scale

0.763

High

378182

TNFA
Tumor necrosis factor

19

3

Small-scale

0.763

High

1430013

NEMO
NF-kappa-B essential modulator

9

6

Small-scale

0.754

High

1384817

OTUL
Ubiquitin thioesterase otulin

5

1

Small-scale

0.702

High

508596

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

4

Small-scale

0.686

High

787584

TNR3
Tumor necrosis factor receptor superfamily member 3

3

5

High-throughput

0.667

High

951849

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

3

1

Small-scale

0.664

High

1429998

RABX5
Rab5 GDP/GTP exchange factor

3

1

High-throughput

0.662

High

1429982

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

3

2

Small-scale

0.656

High

622679

TNR1A
Tumor necrosis factor receptor superfamily member 1A

3

5

Small-scale

0.640

High

639309

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

2

Small-scale

0.635

High

1093950

TRAF1
TNF receptor-associated factor 1

2

5

Small-scale

0.624

High

1429986

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

3

0

Small-scale

0.613

High

543284

UBL4A
Ubiquitin-like protein 4A

2

5

Small-scale

0.611

High

634728

ITAL
Integrin alpha-L

2

7

Small-scale

0.600

High

1213472

DCA12
DDB1- and CUL4-associated factor 12

2

0

Small-scale

0.585

High

1272429

GET4
Golgi to ER traffic protein 4 homolog

2

0

Small-scale

0.585

High

353899

BCL10
B-cell lymphoma/leukemia 10

2

1

Small-scale

0.584

High

1429996

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

2

1

Small-scale

0.584

High

1430000

SPAT2
Spermatogenesis-associated protein 2

2

1

Small-scale

0.584

High

1186707

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1155038

ADIPO
Adiponectin

2

0

High-throughput

0.576

High

473719

ITA5
Integrin alpha-5

2

7

Small-scale

0.574

High

681922

RBTN2
Rhombotin-2

2

3

High-throughput

0.574

High

958346

ARP2
Actin-related protein 2

1

2

Small-scale

0.561

High

1151071

PCH2
Pachytene checkpoint protein 2 homolog

2

1

High-throughput

0.553

High

1430012

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

4

Small-scale

0.552

High

603809

ITA2
Integrin alpha-2

1

7

Small-scale

0.545

High

900149

FXR1
RNA-binding protein FXR1

1

2

High-throughput

0.541

High

1056964

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.541

High

1417953

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

High-throughput

0.541

High

167970

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

3

Small-scale

0.536

High

177944

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

3

Small-scale

0.536

High

214029

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.536

High

216126

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

1

High-throughput

0.536

High

359874

DYR
Dihydrofolate reductase

1

1

High-throughput

0.536

High

361921

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

1

High-throughput

0.536

High

537880

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.536

High

693363

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

1

High-throughput

0.536

High

902057

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.536

High

931596

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.536

High

968659

NCS1
Neuronal calcium sensor 1

1

1

High-throughput

0.536

High

1094979

TRAF3
TNF receptor-associated factor 3

1

9

High-throughput

0.536

High

1138036

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.536

High

1244486

ULK3
Serine/threonine-protein kinase ULK3

1

1

High-throughput

0.536

High

1245062

TRI65
E3 ubiquitin-protein ligase TRIM65

1

4

High-throughput

0.536

High

1295181

PDPN
Podoplanin

1

1

High-throughput

0.536

High

1295745

HIPK1
Homeodomain-interacting protein kinase 1

1

1

High-throughput

0.536

High

1311677

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

5

High-throughput

0.536

High

1339703

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.536

High

1406026

PHB2
Prohibitin-2

1

2

High-throughput

0.536

High

1414646

TCAB1
Telomerase Cajal body protein 1

1

1

High-throughput

0.536

High

1429221

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

2

High-throughput

0.536

High

1429981

ZN703
Zinc finger protein 703

1

1

High-throughput

0.536

High

1429993

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

High-throughput

0.536

High

1429995

DNJB4
DnaJ homolog subfamily B member 4

1

1

High-throughput

0.536

High

1430003

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.536

High

1092491

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

0

High-throughput

0.518

High

174399

ZN609
Zinc finger protein 609

1

0

High-throughput

0.513

High

716490

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

1

0

High-throughput

0.513

High

724513

GDIA
Rab GDP dissociation inhibitor alpha

1

0

High-throughput

0.513

High

1153110

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.513

High

1179194

CTC1
CST complex subunit CTC1

1

0

High-throughput

0.513

High

1243298

MEAK7
MTOR-associated protein MEAK7

1

0

High-throughput

0.513

High

1287886

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

1349882

ZN507
Zinc finger protein 507

1

0

High-throughput

0.513

High

1365667

LAR4B
La-related protein 4B

1

0

High-throughput

0.513

High

1406487

ATX2
Ataxin-2

1

0

High-throughput

0.513

High

1419905

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.513

High

1429990

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

0

High-throughput

0.513

High

1429992

MIOS
GATOR2 complex protein MIOS

1

0

High-throughput

0.513

High

1430006

NISCH
Nischarin

1

0

High-throughput

0.513

High

470429

ITA2B
Integrin alpha-IIb

1

7

Small-scale

0.512

High

940356

ITA1
Integrin alpha-1

1

7

Small-scale

0.512

High

958189

ARP3
Actin-related protein 3

1

2

Small-scale

0.501

High

1417848

RNF26
E3 ubiquitin-protein ligase RNF26

1

4

Small-scale

0.501

High

424104

ITB2
Integrin beta-2

1

2

Small-scale

0.489

High

91601

UMAD1
UBAP1-MVB12-associated

1

1

High-throughput

0.489

High

1066248

DMWD
Dystrophia myotonica WD repeat-containing protein

1

1

High-throughput

0.489

High

1191971

TBB8
Tubulin beta-8 chain

1

4

High-throughput

0.489

High

1248290

MOXD1
DBH-like monooxygenase protein 1

1

1

High-throughput

0.489

High

1294311

VP37D
Vacuolar protein sorting-associated protein 37D

1

1

High-throughput

0.489

High

1339961

O52N4
Olfactory receptor 52N4

1

1

High-throughput

0.489

High

1340048

O52N5
Olfactory receptor 52N5

1

1

High-throughput

0.489

High

1372192

MED12
Mediator of RNA polymerase II transcription subunit 12

1

2

High-throughput

0.489

High

1420092

ULBP3
UL16-binding protein 3

1

1

High-throughput

0.489

High

1429994

TEN3
Teneurin-3

1

1

High-throughput

0.489

High

1218660

OTU1
Ubiquitin thioesterase OTU1

1

1

Small-scale

0.481

High

1430008

ZBT32
Zinc finger and BTB domain-containing protein 32

1

2

High-throughput

0.481

High

165413

PSA7
Proteasome subunit alpha type-7

1

4

Small-scale

0.479

High

191238

TLR3
Toll-like receptor 3

1

2

Small-scale

0.479

High

396910

ESR1
Estrogen receptor

1

1

Small-scale

0.479

High

451070

LDHB
L-lactate dehydrogenase B chain

1

4

Small-scale

0.479

High

681021

PSA1
Proteasome subunit alpha type-1

1

5

Small-scale

0.479

High

681512

PSA3
Proteasome subunit alpha type-3

1

4

Small-scale

0.479

High

681718

PSA4
Proteasome subunit alpha type-4

1

5

Small-scale

0.479

High

712890

CASP1
Caspase-1

1

1

Small-scale

0.479

High

765024

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

833683

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.479

High

856911

BAG6
Large proline-rich protein BAG6

1

3

Small-scale

0.479

High

862441

YAP1
Transcriptional coactivator YAP1

1

3

Small-scale

0.479

High

887723

PSB2
Proteasome subunit beta type-2

1

1

Small-scale

0.479

High

954905

PSA6
Proteasome subunit alpha type-6

1

5

Small-scale

0.479

High

978715

RL23A
Large ribosomal subunit protein uL23

1

1

Small-scale

0.479

High

979222

RS6
Small ribosomal subunit protein eS6

1

1

Small-scale

0.479

High

1095797

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

Small-scale

0.479

High

1114257

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1336839

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

Small-scale

0.479

High

1391040

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.479

High

1429978

ZBP1
Z-DNA-binding protein 1

1

1

Small-scale

0.479

High

1429987

PDLI7
PDZ and LIM domain protein 7

1

1

Small-scale

0.479

High

1429988

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

1

Small-scale

0.479

High

1429999

AGO2
Protein argonaute-2

1

1

Small-scale

0.479

High

1430001

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

1430007

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

5

Small-scale

0.479

High

1430010

TRAF6
TNF receptor-associated factor 6

1

9

Small-scale

0.479

High

1430011

RN114
E3 ubiquitin-protein ligase RNF114

1

6

Small-scale

0.479

High

2914

A0A0C4DGF1
Zinc finger and BTB domain containing 32

1

1

High-throughput

0.470

High

128317

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.458

High

162692

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

179398

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.458

High

215347

TXNL1
Thioredoxin-like protein 1

1

0

Small-scale

0.458

High

295408

CBR3
Carbonyl reductase [NADPH] 3

1

0

Small-scale

0.458

High

347312

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.458

High

378520

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

555424

SKI
Ski oncogene

1

0

Small-scale

0.458

High

716459

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

Small-scale

0.458

High

788333

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

0

Small-scale

0.458

High

822859

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

851419

PRS6B
26S proteasome regulatory subunit 6B

1

0

Small-scale

0.458

High

887590

PSB3
Proteasome subunit beta type-3

1

0

Small-scale

0.458

High

895044

EMD
Emerin

1

0

Small-scale

0.458

High

906600

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

Small-scale

0.458

High

921569

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

0

Small-scale

0.458

High

922772

CCHL
Holocytochrome c-type synthase

1

0

Small-scale

0.458

High

949207

TPIS
Triosephosphate isomerase

1

0

Small-scale

0.458

High

967958

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.458

High

1028388

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1129878

EPN4
Clathrin interactor 1

1

0

Small-scale

0.458

High

1348826

NANP
N-acylneuraminate-9-phosphatase

1

0

Small-scale

0.458

High

1391754

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

1405612

TSNAX
Translin-associated protein X

1

0

Small-scale

0.458

High

1406565

METH
Methionine synthase

1

0

Small-scale

0.458

High

1429980

STEEP
STING ER exit protein

1

0

Small-scale

0.458

High

1429983

RAB18
Ras-related protein Rab-18

1

0

Small-scale

0.458

High

1429984

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

Small-scale

0.458

High

1429985

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

0

Small-scale

0.458

High

1429991

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

0

Small-scale

0.458

High

1430002

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

Small-scale

0.458

High

841082

HELZ
Probable helicase with zinc finger domain

1

1

High-throughput

0.445

High

1105267

MKRN4
Putative E3 ubiquitin-protein ligase makorin-4

1

2

High-throughput

0.445

High

1107195

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

Small-scale

0.445

High

1107477

BIRC2
Baculoviral IAP repeat-containing protein 2

1

3

Small-scale

0.445

High

1367942

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

1040207

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

6

Small-scale

0.437

High

1393494

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

Small-scale

0.437

High

1430005

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

4

Small-scale

0.408

High

1353532

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

1

Small-scale

0.407

High

539494

ITAM
Integrin alpha-M

1

7

Small-scale

0.373

High

1102958

ITAD
Integrin alpha-D

1

7

Small-scale

0.373

High

450204

LIPF
Gastric triacylglycerol lipase

3

0

High-throughput

0.347

High

1258183

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

1307118

KRA71
Keratin-associated protein 7-1

2

0

High-throughput

0.316

High

270478

FZD7
Frizzled-7

1

0

High-throughput

0.279

Low

326445

S1PR2
Sphingosine 1-phosphate receptor 2

1

0

High-throughput

0.279

Low

710476

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.279

Low

885604

PRI2
DNA primase large subunit

1

0

High-throughput

0.279

Low

1130664

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.279

Low

1180185

QRIC1
Transcriptional regulator QRICH1

1

0

High-throughput

0.279

Low

1225968

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

1229505

C19L1
CWF19-like protein 1

1

0

High-throughput

0.279

Low

1233879

RTL6
Retrotransposon Gag-like protein 6

1

0

High-throughput

0.279

Low

1250658

BCOR
BCL-6 corepressor

1

0

High-throughput

0.279

Low

1293472

NIT1
Deaminated glutathione amidase

1

0

High-throughput

0.279

Low

1387007

ORAI1
Calcium release-activated calcium channel protein 1

1

0

High-throughput

0.279

Low

1399258

SAM11
Sterile alpha motif domain-containing protein 11

1

0

High-throughput

0.279

Low

1402364

CSRN1
Cysteine/serine-rich nuclear protein 1

1

0

High-throughput

0.279

Low

1429989

SEM4G
Semaphorin-4G

1

0

High-throughput

0.279

Low

1430004

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.279

Low

1430009

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.279

Low

1429979

PPIL3
Peptidyl-prolyl cis-trans isomerase-like 3

1

0

Small-scale

0.261

Low

1407194

THIOM
Thioredoxin, mitochondrial

1

0

High-throughput

0.251

Low

1250039

WDR82
WD repeat-containing protein 82

1

0

Small-scale

0.249

Low

1351874

NEK7
Serine/threonine-protein kinase Nek7

1

0

Small-scale

0.249

Low

1429997

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

719513

BKRB2
B2 bradykinin receptor

1

0

Small-scale

0.238

Low

329585

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.232

Low

628460

KLK2
Kallikrein-2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025