HitPredict

Interactor 1: DDX3X (O00571)
ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)
Gene: DDX3X

Interactor 2: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	17353931, 29395067
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DEAD~DEAD, DEAD~Helicase_C, Helicase_C~Helicase_C
Common GO terms	GO:0003723 - RNA binding GO:0003724 - RNA helicase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006413 - translational initiation and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 662 Hs			1 407
+	Hs
		133951 DDX3X_HUMAN (1-662): 0: 614: 100.00		IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88
+	Hs
		134146 DDX3X_HUMAN (1-662): 0: 614: 100.00		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		133874 DDX3X_HUMAN (1-662): 0: 614: 100.00		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Hs
		133911 DDX3X_HUMAN (1-662): 0: 614: 100.00		IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65
+	Sc
		415868 DED1_YEAST (10-633): 3.96e-151: 452: 47.28		IF4A_YEAST (24-407): 7e-167: 474: 65.89
+	Sc
		624206 DBP1_YEAST (10-660): 1.65e-166: 492: 48.54		DBP1_YEAST (4-406): 3.09e-127: 382: 31.52
+	Hs
		571538 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		571300 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30
+	Hs
		1271612 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20
+	Hs
		757701 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65
+	Sc
		415893 DED1_YEAST (10-633): 3.96e-151: 452: 47.28		DBP1_YEAST (4-406): 3.09e-127: 382: 31.52
+	Sc
		624023 DBP2_YEAST (72-578): 2.04e-147: 440: 37.31		DBP2_YEAST (22-405): 1.21e-131: 390: 32.65
+	Sc
		415974 DED1_YEAST (10-633): 3.96e-151: 452: 47.28		DHH1_YEAST (33-403): 1.13e-98: 305: 43.67
+	Ce
		650025 GLH1_CAEEL (157-575): 1.85e-104: 336: 42.99		IF4A_CAEEL (6-407): 2.09e-131: 385: 70.15