HitPredict

Interactor 1: SAP18 (O00422)
Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)
Gene: SAP18

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	33961781, 39522233
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~SAP18
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0016607 - nuclear speck
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 153 Hs			1 248
+	Hs
		134713 SAP18_HUMAN (1-153): 2.05e-90: 261: 100.00		SRSF9_HUMAN (1-239): 4.19e-66: 206: 60.25
+	Hs
		134714 SAP18_HUMAN (1-153): 2.05e-90: 261: 100.00		SRSF5_HUMAN (14-183): 8.07e-61: 194: 41.48
+	Hs
		134715 SAP18_HUMAN (1-153): 2.05e-90: 261: 100.00		SRSF6_HUMAN (17-200): 2.59e-57: 187: 40.51
+	Hs
		134699 SAP18_HUMAN (1-153): 2.05e-90: 261: 100.00		SRSF4_HUMAN (17-243): 1.37e-49: 171: 37.66
+	Hs
		134542 SAP18_HUMAN (1-153): 2.05e-90: 261: 100.00		PABP1_HUMAN (7-203): 1.69e-37: 140: 17.07
+	Hs
		134679 SAP18_HUMAN (1-153): 2.05e-90: 261: 100.00		SRSF3_HUMAN (15-99): 9.37e-28: 105: 43.53
+	Hs
		134755 SAP18_HUMAN (1-153): 2.05e-90: 261: 100.00		SRSF7_HUMAN (14-105): 7.37e-23: 94.8: 40.22
+	Hs
		134716 SAP18_HUMAN (1-153): 2.05e-90: 261: 100.00		PABP4_HUMAN (116-203): 1.15e-12: 68.9: 16.84