HitPredict

Interactor 1: CCL22 (O00626)
C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]
Gene: CCL22

Interactor 2: CCR4 (P51679)
C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
Gene: CCR4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	9430724
Identification Methods	pull down, biochemical, saturation binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0006955 - immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 93 Hs			1 360
+	Hs
		486238 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CCR4_HUMAN (1-360): 2.26e-90: 277: 100.00
+	Hs
		134356 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30
+	Hs
		134354 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30
+	Hs
		134400 CCL13_HUMAN (3-93): 1.09e-30: 105: 29.67		ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30
+	Mm
		139696 CCL2_MOUSE (3-93): 5.06e-30: 105: 27.17		ACKR2_MOUSE (3-351): 4.29e-86: 266: 35.61
+	Hs
		561728 CL3L1_HUMAN (3-92): 1.08e-32: 110: 28.89		CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11
+	Mm
		486358 CCL2_MOUSE (3-93): 5.06e-30: 105: 27.17		CCR2_MOUSE (18-360): 1.65e-80: 252: 47.67
+	Hs
		526560 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11
+	Hs
		486230 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11
+	Mm
		500591 CCL3_MOUSE (3-92): 5.84e-31: 106: 31.11		CCR3_MOUSE (1-357): 6.16e-79: 247: 45.40
+	Hs
		561733 CL3L1_HUMAN (3-92): 1.08e-32: 110: 28.89		CCR5_HUMAN (25-360): 1.7e-71: 228: 49.70
+	Mm
		500590 CCL3_MOUSE (3-92): 5.84e-31: 106: 31.11		CCR1_MOUSE (5-360): 1.83e-72: 230: 44.69
+	Hs
		561732 CL3L1_HUMAN (3-92): 1.08e-32: 110: 28.89		CCR3_HUMAN (14-357): 1.14e-70: 226: 45.38
+	Hs
		526565 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		CCR5_HUMAN (25-360): 1.7e-71: 228: 49.70
+	Hs
		486239 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CCR5_HUMAN (25-360): 1.7e-71: 228: 49.70
+	Hs
		526564 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		CCR3_HUMAN (14-357): 1.14e-70: 226: 45.38
+	Hs
		486237 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CCR3_HUMAN (14-357): 1.14e-70: 226: 45.38
+	Hs
		526561 CCL4_HUMAN (3-92): 2.18e-31: 107: 33.33		CXCR5_HUMAN (16-330): 6e-47: 165: 34.26
+	Hs
		486231 CCL3_HUMAN (3-92): 4.9e-31: 106: 30.00		CXCR5_HUMAN (16-330): 6e-47: 165: 34.26
+	Mm
		192790 CCL2_MOUSE (3-93): 5.06e-30: 105: 27.17		CCRL2_MOUSE (49-322): 2.16e-41: 150: 32.62