HitPredict

Interactor 1: IMA3 (O00629)
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)
Gene: KPNA4

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 521 Hs			1 465
+	Hs
		131348 IMA4_HUMAN (1-521): 2.77e-161: 469: 85.80		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226926 IMA1_HUMAN (1-521): 1.39e-145: 430: 49.62		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226007 IMA7_HUMAN (1-521): 3.56e-142: 421: 46.46		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		168603 IMA6_HUMAN (1-521): 7.28e-137: 408: 46.75		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226927 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Dm
		284385 Q9V455_DROME (6-521): 4.38e-142: 420: 65.96		ARI2_DROME (228-464): 7.29e-69: 229: 20.92
+	Hs
		853500 IMA1_HUMAN (1-521): 1.39e-145: 430: 49.62		AKIB1_HUMAN (238-456): 1.26e-60: 215: 21.55
+	At
		1091951 IMPA1_ARATH (1-521): 3.44e-158: 462: 43.72		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		97780 IMPA2_ARATH (1-521): 1.4e-157: 461: 44.69		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		285378 IMPA4_ARATH (1-521): 2.9e-155: 455: 41.64		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17