HitPredict

Interactor 1: ABI2 (Q9NYB9)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Interactor 2: WASF3 (Q9UPY6)
Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3)
Gene: WASF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	32296183, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0007010 - cytoskeleton organization GO:0030027 - lamellipodium GO:0031209 - SCAR complex GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 513 Hs			1 502
+	Hs
		1224659 ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00		WASF3_HUMAN (1-502): 1.19e-73: 243: 100.00
+	Mm
		1206472 ABI1_MOUSE (1-513): 2.82e-100: 312: 60.04		WASF2_MOUSE (1-484): 9.89e-66: 222: 42.56
+	Hs
		1224624 ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00		WASF1_HUMAN (1-500): 3.42e-59: 206: 43.57
+	Hs
		1224667 ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Rn
		1124757 ABI1_RAT (1-513): 4.31e-96: 301: 59.45		WASF1_RAT (1-500): 1.87e-56: 199: 43.04
+	Hs
		1267032 ABI2_HUMAN (1-513): 1.82e-91: 290: 100.00		WASF1_HUMAN (1-500): 3.42e-59: 206: 43.57
+	Hs
		1348444 ABI2_HUMAN (1-513): 1.82e-91: 290: 100.00		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Dm
		94647 Q9Y0S9_DROME (1-507): 5.88e-73: 240: 34.91		F2FB81_DROME (1-209): 1.43e-42: 162: 54.55
+	Hs
		1052366 SRC8_HUMAN (271-507): 2.78e-32: 131: 17.84		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Rn
		192742 SRBS2_RAT (293-509): 7.62e-17: 85.9: 14.35		Q5FWU0_RAT (1-484): 3.53e-64: 218: 42.77
+	Dm
		94643 DBNL_DROME (204-508): 7.74e-33: 133: 20.94		F2FB81_DROME (1-209): 1.43e-42: 162: 54.55
+	Hs
		298991 SRBS2_HUMAN (373-509): 1.11e-16: 85.5: 19.87		WASF1_HUMAN (1-500): 3.42e-59: 206: 43.57
+	Hs
		1267036 ABI3_HUMAN (262-507): 4.36e-17: 84.9: 23.17		WASF1_HUMAN (1-500): 3.42e-59: 206: 43.57
+	Hs
		203224 MYO1E_HUMAN (325-508): 7.96e-32: 132: 22.68		SYNJ1_HUMAN (11-499): 4.06e-38: 151: 11.82
+	Rn
		192744 SRBS2_RAT (293-509): 7.62e-17: 85.9: 14.35		SYNJ1_RAT (11-480): 2.46e-43: 166: 12.19
+	Dd
		1122140 ABIA_DICDI (3-255): 4.63e-29: 119: 19.46		SCAR_DICDI (23-501): 1.2e-28: 119: 22.04
+	Hs
		203192 SRBS2_HUMAN (373-509): 1.11e-16: 85.5: 19.87		SYNJ1_HUMAN (11-499): 4.06e-38: 151: 11.82
+	Hs
		1021688 MYO1E_HUMAN (325-508): 7.96e-32: 132: 22.68		CBP_HUMAN (153-498): 1.18e-22: 104: 13.84
+	Hs
		587810 NCF2_HUMAN (112-506): 1.79e-26: 114: 13.28		CBP_HUMAN (153-498): 1.18e-22: 104: 13.84
+	Sp
		194039 MYO1_SCHPO (306-507): 8.58e-30: 126: 18.45		YFHH_SCHPO (254-438): 5.42e-09: 61.1: 18.72