HitPredict - High confidence protein-protein interactions

Interactor 1: M3K20 (Q9NYL2)
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
Gene: MAP3K20

Interactor 2: M3K20 (Q9NYL2)
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
Gene: MAP3K20

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	15485649, 10924358
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, acetylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1, SAM_1~SAM_1
Common GO terms	GO:0000077 - DNA damage checkpoint signaling GO:0000165 - MAPK cascade GO:0000287 - magnesium ion binding GO:0003723 - RNA binding GO:0004674 - protein serine/threonine kinase activity and 34 others more... GO:0004706 - JUN kinase kinase kinase activity GO:0004709 - MAP kinase kinase kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0006954 - inflammatory response GO:0007010 - cytoskeleton organization GO:0007059 - chromosome segregation GO:0007254 - JNK cascade GO:0008219 - cell death GO:0030071 - regulation of mitotic metaphase/anaphase transition GO:0030154 - cell differentiation GO:0030295 - protein kinase activator activity GO:0031098 - stress-activated protein kinase signaling cascade GO:0038066 - p38MAPK cascade GO:0042733 - embryonic digit morphogenesis GO:0043022 - ribosome binding GO:0043065 - positive regulation of apoptotic process GO:0043068 - positive regulation of programmed cell death GO:0046777 - protein autophosphorylation GO:0051403 - stress-activated MAPK cascade GO:0060173 - limb development GO:0071493 - cellular response to UV-B GO:0070181 - small ribosomal subunit rRNA binding GO:0070269 - pyroptotic inflammatory response GO:0070303 - negative regulation of stress-activated protein kinase signaling cascade GO:0071480 - cellular response to gamma radiation GO:0106310 - protein serine kinase activity GO:0140469 - GCN2-mediated signaling GO:0170011 - stalled ribosome sensor activity GO:1902010 - negative regulation of translation in response to endoplasmic reticulum stress GO:1904291 - positive regulation of mitotic DNA damage checkpoint
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1	800
Hs

1	800

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Last updated: 15 Jul 2024