HitPredict

Interactor 1: IMA3 (O00629)
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)
Gene: KPNA4

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	26496610, 35271311, 23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 521 Hs			1 482
+	Hs
		134940 IMA3_HUMAN (1-521): 1.57e-165: 480: 100.00		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		131432 IMA4_HUMAN (1-521): 2.77e-161: 469: 85.80		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		131481 IMA4_HUMAN (1-521): 2.77e-161: 469: 85.80		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		853269 IMA1_HUMAN (1-521): 1.39e-145: 430: 49.62		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		853401 IMA1_HUMAN (1-521): 1.39e-145: 430: 49.62		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		238671 IMA7_HUMAN (1-521): 3.56e-142: 421: 46.46		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		238715 IMA7_HUMAN (1-521): 3.56e-142: 421: 46.46		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		853589 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		853672 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Sp
		223485 IMA2_SCHPO (8-521): 3.88e-137: 409: 45.49		CLR6_SCHPO (8-405): 0: 563: 62.10
+	Hs
		853744 IMA5_HUMAN (3-521): 4.55e-135: 403: 45.46		HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78
+	Zm
		9933 C0PBU6_MAIZE (9-488): 1.69e-83: 270: 25.34		A0A1D6F0N8_MAIZE (11-479): 2.65e-140: 420: 22.67