HitPredict

Interactor 1: KCIP1 (Q9NZI2)
Kv channel-interacting protein 1 (KChIP1) (A-type potassium channel modulatory protein 1) (Potassium channel-interacting protein 1) (Vesicle APC-binding protein)
Gene: KCNIP1

Interactor 2: KCND2 (Q9NZV8)
Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)
Gene: KCND2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	14980207, 10676964, 15358149
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	EF-hand_7~Ion_trans, EF-hand_7~Shal-type, BTB_2~EF-hand_8, EF-hand_8~Shal-type
Common GO terms	GO:0005886 - plasma membrane GO:0008076 - voltage-gated potassium channel complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 227 Hs			1 630
+	Rn
		1144387 KCIP1_RAT (1-227): 5.24e-63: 197: 99.12		KCND2_RAT (1-630): 0: 626: 99.05
+	Hs
		1345312 KCIP2_HUMAN (32-227): 2.59e-54: 176: 71.43		KCND2_HUMAN (1-630): 0: 625: 100.00
+	Rn
		1144388 KCIP2_RAT (32-227): 3.63e-53: 173: 71.43		KCND2_RAT (1-630): 0: 626: 99.05
+	Mm
		1337485 KCIP2_MOUSE (32-227): 3.4e-53: 174: 71.43		KCND2_MOUSE (1-630): 0: 625: 99.05
+	Hs
		1349468 CSEN_HUMAN (32-227): 3.84e-52: 170: 69.90		KCND2_HUMAN (1-630): 0: 625: 100.00
+	Hs
		906793 NCS1_HUMAN (38-227): 2.58e-49: 161: 43.68		KCND2_HUMAN (1-630): 0: 625: 100.00
+	Hs
		1349120 KCIP1_HUMAN (1-227): 2.5e-63: 198: 100.00		KCND3_HUMAN (1-626): 0: 572: 73.99
+	Hs
		1345313 KCIP2_HUMAN (32-227): 2.59e-54: 176: 71.43		KCND3_HUMAN (1-626): 0: 572: 73.99
+	Dm
		572848 Q9VBL2_DROME (32-225): 4.21e-46: 154: 51.80		KCNAL_DROME (3-539): 5.72e-164: 482: 68.09
+	Ce
		108347 G5EGM2_CAEEL (46-227): 1.61e-42: 145: 34.62		Q95XD1_CAEEL (3-576): 3.17e-163: 481: 56.55