Protein: EHD4
EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4)

Gene: EHD4
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q9H223

Gene Ontology (top 5):
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0003676 - nucleic acid binding
GO:0005509 - calcium ion binding
GO:0005524 - ATP binding
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1431442

EHD2
EH domain-containing protein 2

3

15

High-throughput

0.855

High

1431435

EHD1
EH domain-containing protein 1

3

15

High-throughput

0.847

High

1431441

EHD3
EH domain-containing protein 3

2

15

High-throughput

0.789

High

1315128

EXOC8
Exocyst complex component 8

2

1

High-throughput

0.628

High

1390296

TRI11
E3 ubiquitin-protein ligase TRIM11

2

4

High-throughput

0.628

High

1431134

RBNS5
Rabenosyn-5

2

5

High-throughput

0.628

High

1431432

EHD4
EH domain-containing protein 4

1

14

High-throughput

0.618

High

1203498

ACTMP
Actin maturation protease

2

1

High-throughput

0.611

High

1325136

MILK1
MICAL-like protein 1

2

6

Small-scale

0.611

High

242892

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

446043

ENOA
Alpha-enolase

2

1

High-throughput

0.584

High

1119632

RGRF1
Ras-specific guanine nucleotide-releasing factor 1

1

6

High-throughput

0.541

High

259100

DNJA2
DnaJ homolog subfamily A member 2

1

4

High-throughput

0.536

High

1026220

CLH1
Clathrin heavy chain 1

1

6

High-throughput

0.536

High

1111261

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1124538

MAP7
Ensconsin

1

20

High-throughput

0.536

High

1157063

NTRK3
NT-3 growth factor receptor

1

18

High-throughput

0.536

High

1349116

F174A
Membrane protein FAM174A

1

1

High-throughput

0.536

High

1383853

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1395113

TMX3
Protein disulfide-isomerase TMX3

1

2

High-throughput

0.536

High

1404389

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1417053

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.536

High

1431438

VPS45
Vacuolar protein sorting-associated protein 45

1

1

High-throughput

0.536

High

1431447

NTNG1
Netrin-G1

1

1

High-throughput

0.536

High

390260

FETA
Alpha-fetoprotein

1

0

High-throughput

0.518

High

165822

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

0

High-throughput

0.513

High

301974

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.513

High

1195269

TM52B
Transmembrane protein 52B

1

0

High-throughput

0.513

High

1214375

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

1219234

CDCP2
CUB domain-containing protein 2

1

0

High-throughput

0.513

High

1431437

PCDBG
Protocadherin beta-16

1

0

High-throughput

0.513

High

955575

CDC42
Cell division control protein 42 homolog

1

18

High-throughput

0.501

High

964453

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

1208214

SPXN5
Sperm protein associated with the nucleus on the X chromosome N5

1

3

High-throughput

0.489

High

1340743

TPC2
Two pore channel protein 2

1

2

High-throughput

0.489

High

1431451

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

48785

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.479

High

126791

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

326033

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

High-throughput

0.479

High

343050

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.479

High

363841

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.479

High

373122

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

375935

RASK
GTPase KRas

1

13

High-throughput

0.479

High

412588

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.479

High

418429

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

537892

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

540667

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.479

High

556335

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

589657

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

630038

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

631465

RAB5A
Ras-related protein Rab-5A

1

7

High-throughput

0.479

High

696474

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

845796

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

872737

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

888326

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

945094

RAB25
Ras-related protein Rab-25

1

6

High-throughput

0.479

High

976551

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.479

High

988694

RAC1
Ras-related C3 botulinum toxin substrate 1

1

16

High-throughput

0.479

High

1030689

ANK2
Ankyrin-2

1

12

Small-scale

0.479

High

1067708

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

1100367

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

1107199

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1114271

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1151865

RHOH
Rho-related GTP-binding protein RhoH

1

17

High-throughput

0.479

High

1152469

T22D1
TSC22 domain family protein 1

1

3

High-throughput

0.479

High

1155756

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1233473

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1233658

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

1

High-throughput

0.479

High

1255494

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

1270987

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1276310

ATG9A
Autophagy-related protein 9A

1

4

High-throughput

0.479

High

1276772

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1330929

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.479

High

1334556

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.479

High

1362004

RFFL
E3 ubiquitin-protein ligase rififylin

1

8

Small-scale

0.479

High

1366878

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1380654

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1405850

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

1413723

FSD1
Fibronectin type III and SPRY domain-containing protein 1

1

12

High-throughput

0.479

High

1430578

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1431314

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

1431433

RHOJ
Rho-related GTP-binding protein RhoJ

1

19

High-throughput

0.479

High

1431434

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1431436

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1431439

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1431445

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

15

High-throughput

0.479

High

1431449

TRI17
E3 ubiquitin-protein ligase TRIM17

1

4

Small-scale

0.479

High

129415

MEN1
Menin

1

0

High-throughput

0.458

High

276175

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.458

High

294314

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

705725

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

0

High-throughput

0.458

High

789015

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

1218990

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

1312598

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1429344

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1431444

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.458

High

1431448

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

1431450

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.458

High

261273

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.445

High

598770

ANFB
Natriuretic peptides B

1

2

High-throughput

0.445

High

967964

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.445

High

1199692

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

1209642

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

1366226

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

1394676

KIRR1
Kin of IRRE-like protein 1

1

1

High-throughput

0.445

High

1431440

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

1

High-throughput

0.445

High

1431446

GAB2
GRB2-associated-binding protein 2

1

7

High-throughput

0.445

High

568499

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

769144

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1431443

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

248941

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

437788

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

466967

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.426

High

607987

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.426

High

1053066

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.426

High

1332507

POC5
Centrosomal protein POC5

1

0

Small-scale

0.426

High

1333497

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.426

High

330310

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

1104092

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

139410

VMA5A
von Willebrand factor A domain-containing protein 5A

1

0

High-throughput

0.279

Low

347317

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

1329548

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

1399523

NOE3
Noelin-3

1

0

High-throughput

0.279

Low

1431452

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

0

High-throughput

0.269

Low

71402

HECA2
HEPACAM family member 2

1

0

High-throughput

0.249

Low

1414739

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.249

Low

653563

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1239293

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1325789

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025