HitPredict

Interactor 1: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~SH3_1, SH3_1~SH3_2, SH3_2~SH3_9
Common GO terms	GO:0005886 - plasma membrane GO:0035633 - maintenance of blood-brain barrier GO:0045216 - cell-cell junction organization GO:0045296 - cadherin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1190 Hs			1 639
+	Hs
		1285211 ZO2_HUMAN (1-1190): 0: 838: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		209185 ZO2_HUMAN (1-1190): 0: 838: 100.00		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		1167833 ZO2_HUMAN (1-1190): 0: 838: 100.00		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		1126376 ZO2_HUMAN (1-1190): 0: 838: 100.00		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Hs
		990871 ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		990858 ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Mm
		1143451 DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89		SH3K1_MOUSE (1-638): 2.12e-83: 278: 30.09
+	Hs
		1232491 PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Mm
		223014 DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89		NCK2_MOUSE (2-361): 1.08e-58: 203: 16.58
+	Hs
		159209 CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09		ARHG7_HUMAN (176-378): 4.79e-13: 74.6: 20.87
+	Mm
		1141133 DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		924466 DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1143326 DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89		SRBS1_MOUSE (58-326): 2.72e-19: 94.7: 17.93
+	Mm
		1143413 DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89		SH3R3_MOUSE (45-590): 9.65e-12: 70.3: 12.11
+	Mm
		1113245 DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89		SRBS2_MOUSE (258-329): 5.28e-09: 61.5: 20.83
+	Hs
		557746 DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		235554 DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28