HitPredict

Interactor 1: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 0.60 0.757

The method score is based on:

Property Details
Experiments 23028469, 26611359, 28514442, 14743216, 30561431, 33961781, 35289316, 20098747, 21903422, 12133833
Identification Methods affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation, protein array, virotrap
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006954 - inflammatory response
GO:0007249 - canonical NF-kappaB signal transduction
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 729
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024