Protein: SRGP2
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)

Gene: SRGP2, SRGAP2
Organism: Homo sapiens
Interactions: 166
UniProt ID: O75044

Gene Ontology (top 5):
GO:0003363 - lamellipodium assembly involved in ameboidal cell migration
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

200200

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

3

17

High-throughput

0.861

High

253290

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

2

17

Small-scale

0.811

High

253337

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.754

High

253374

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

2

17

High-throughput

0.737

High

253334

1433G
14-3-3 protein gamma

6

20

High-throughput

0.735

High

253338

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.718

High

253321

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.716

High

253342

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

253315

1433T
14-3-3 protein theta

4

20

High-throughput

0.683

High

253336

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

4

High-throughput

0.665

High

253380

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

5

High-throughput

0.628

High

253300

RASK
GTPase KRas

1

18

High-throughput

0.618

High

253302

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

253304

SRG2C
SLIT-ROBO Rho GTPase-activating protein 2C

1

18

Small-scale

0.618

High

253307

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

253311

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

253317

EPHB2
Ephrin type-B receptor 2

1

13

High-throughput

0.618

High

253332

ACTB
Actin, cytoplasmic 1

1

17

High-throughput

0.618

High

253333

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

253341

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

253347

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

7

High-throughput

0.618

High

253355

EPHA7
Ephrin type-A receptor 7

1

14

High-throughput

0.618

High

253360

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

9

High-throughput

0.618

High

253361

SPD2A
SH3 and PX domain-containing protein 2A

1

20

High-throughput

0.618

High

253366

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.618

High

253370

SYDE1
Rho GTPase-activating protein SYDE1

1

17

High-throughput

0.618

High

253371

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

253375

PHLB2
Pleckstrin homology-like domain family B member 2

1

14

High-throughput

0.618

High

253377

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.618

High

253378

KSR1
Kinase suppressor of Ras 1

1

15

High-throughput

0.618

High

253387

DEP1B
DEP domain-containing protein 1B

1

15

High-throughput

0.618

High

253399

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.618

High

253400

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.618

High

253410

PKHA5
Pleckstrin homology domain-containing family A member 5

1

16

High-throughput

0.618

High

253411

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

253421

ITSN2
Intersectin-2

1

8

Small-scale

0.618

High

253433

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

8

High-throughput

0.618

High

253434

GAB2
GRB2-associated-binding protein 2

1

14

High-throughput

0.618

High

253436

STA13
StAR-related lipid transfer protein 13

1

16

High-throughput

0.618

High

253335

1433E
14-3-3 protein epsilon

2

10

High-throughput

0.611

High

153510

ANM5
Protein arginine N-methyltransferase 5

1

3

Small-scale

0.598

High

253328

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

3

Small-scale

0.595

High

253329

YLPM1
YLP motif-containing protein 1

2

2

Small-scale

0.595

High

253415

DISC1
Disrupted in schizophrenia 1 protein

2

2

High-throughput

0.590

High

253405

RTKN
Rhotekin

1

0

High-throughput

0.586

High

253422

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

253298

HERC2
E3 ubiquitin-protein ligase HERC2

2

11

Small-scale

0.584

High

253354

PCM1
Pericentriolar material 1 protein

2

2

High-throughput

0.584

High

253295

FMNL1
Formin-like protein 1

1

6

Small-scale

0.578

High

253417

EXOC1
Exocyst complex component 1

2

1

High-throughput

0.576

High

253301

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

231412

KIF1B
Kinesin-like protein KIF1B

1

4

High-throughput

0.553

High

253365

AN34A
Ankyrin repeat domain-containing protein 34A

1

11

High-throughput

0.553

High

253384

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

High-throughput

0.553

High

253412

TANC2
Protein TANC2

1

7

High-throughput

0.553

High

253432

HECD1
E3 ubiquitin-protein ligase HECTD1

1

9

High-throughput

0.553

High

253297

PCNT
Pericentrin

1

11

High-throughput

0.541

High

253439

ROBO1
Roundabout homolog 1

1

4

Small-scale

0.536

High

253308

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

3

High-throughput

0.536

High

253313

S100P
Protein S100-P

1

9

High-throughput

0.536

High

253339

CSK21
Casein kinase II subunit alpha

1

10

High-throughput

0.536

High

253363

BSPRY
B box and SPRY domain-containing protein

1

6

High-throughput

0.536

High

253406

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

253359

H2B2F
Histone H2B type 2-F

1

15

High-throughput

0.515

High

253393

ZN414
Zinc finger protein 414

1

0

High-throughput

0.513

High

253414

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

2

Small-scale

0.501

High

253396

ODAD1
Outer dynein arm-docking complex subunit 1

1

9

High-throughput

0.489

High

253403

KXDL1
KxDL motif-containing protein 1

1

1

High-throughput

0.489

High

69506

MYO1G
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2

1

4

Small-scale

0.479

High

165802

KDM6B
Lysine-specific demethylase 6B

1

3

Small-scale

0.479

High

166525

DCLK1
Serine/threonine-protein kinase DCLK1

1

8

High-throughput

0.479

High

206670

WIPF1
WAS/WASL-interacting protein family member 1

1

4

Small-scale

0.479

High

237539

DIAP1
Protein diaphanous homolog 1

1

5

Small-scale

0.479

High

253291

TULP3
Tubby-related protein 3

1

3

High-throughput

0.479

High

253292

GGYF1
GRB10-interacting GYF protein 1

1

6

High-throughput

0.479

High

253294

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

4

High-throughput

0.479

High

253299

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

253303

PROF1
Profilin-1

1

10

High-throughput

0.479

High

253309

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

253310

EZRI
Ezrin

1

10

High-throughput

0.479

High

253312

NF1
Neurofibromin

1

6

High-throughput

0.479

High

253314

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.479

High

253318

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

5

High-throughput

0.479

High

253319

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

253320

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

253322

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

253325

WASP
Actin nucleation-promoting factor WAS

1

5

Small-scale

0.479

High

253327

MUC18
Cell surface glycoprotein MUC18

1

6

High-throughput

0.479

High

253330

AFAD
Afadin

1

20

High-throughput

0.479

High

253331

HDAC4
Histone deacetylase 4

1

10

High-throughput

0.479

High

253340

CDK16
Cyclin-dependent kinase 16

1

4

High-throughput

0.479

High

253343

CALD1
Caldesmon

1

17

High-throughput

0.479

High

253345

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

3

High-throughput

0.479

High

253346

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

10

High-throughput

0.479

High

253350

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

253352

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

253353

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

253356

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

17

High-throughput

0.479

High

253358

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.479

High

253362

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

253364

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.479

High

253367

LARP1
La-related protein 1

1

2

High-throughput

0.479

High

253368

GGYF2
GRB10-interacting GYF protein 2

1

14

High-throughput

0.479

High

253369

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

253372

RFIP2
Rab11 family-interacting protein 2

1

8

High-throughput

0.479

High

253373

MYCPP
C-myc promoter-binding protein

1

3

High-throughput

0.479

High

253376

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

253379

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

253381

NAV1
Neuron navigator 1

1

2

High-throughput

0.479

High

253382

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

253383

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.479

High

253386

HDAC7
Histone deacetylase 7

1

10

High-throughput

0.479

High

253388

SRS12
Serine/arginine-rich splicing factor 12

1

6

High-throughput

0.479

High

253389

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

253390

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

253397

FMNL2
Formin-like protein 2

1

5

High-throughput

0.479

High

253402

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

253407

OSBL6
Oxysterol-binding protein-related protein 6

1

3

High-throughput

0.479

High

253409

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

253413

KI13B
Kinesin-like protein KIF13B

1

4

High-throughput

0.479

High

253416

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

3

High-throughput

0.479

High

253425

CING
Cingulin

1

3

High-throughput

0.479

High

253426

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

253427

LIMA1
LIM domain and actin-binding protein 1

1

7

High-throughput

0.479

High

253428

NGAP
Ras GTPase-activating protein nGAP

1

6

High-throughput

0.479

High

253429

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.479

High

253430

ZBT21
Zinc finger and BTB domain-containing protein 21

1

11

High-throughput

0.479

High

253431

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

154105

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

196385

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

230828

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

0

High-throughput

0.458

High

233100

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

237142

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

253296

NADK
NAD kinase

1

0

High-throughput

0.458

High

253324

TALDO
Transaldolase

1

0

High-throughput

0.458

High

253351

MELK
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.458

High

253385

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

253392

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

253395

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

253398

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

253401

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

253404

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

253419

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

253420

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

253423

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

253424

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.458

High

253435

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

253437

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.458

High

253438

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.458

High

253326

HD
Huntingtin

1

7

High-throughput

0.457

High

253344

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.457

High

253394

SPTCS
Spatacsin

1

1

Small-scale

0.457

High

253305

CALM3
Calmodulin-3

1

7

High-throughput

0.445

High

253306

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

253323

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

253348

PAK1
Serine/threonine-protein kinase PAK 1

1

4

Small-scale

0.445

High

253349

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.445

High

100305

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

216888

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.437

High

253293

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

3

Small-scale

0.437

High

253316

CALX
Calnexin

1

2

High-throughput

0.437

High

253391

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

253418

ATD3A
ATPase family AAA domain-containing protein 3A

1

6

Small-scale

0.437

High

253408

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

253357

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024