HitPredict

Interactor 1: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Interactor 2: SRPK3 (Q9UPE1)
SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23)
Gene: SRPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 559 Hs			1 567
+	Hs
		1054671 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		SRPK3_HUMAN (27-567): 5.16e-140: 418: 100.00
+	Hs
		625633 PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		943008 PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		1302090 PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		942653 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		833880 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		1054522 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		SRPK1_HUMAN (368-566): 2.74e-59: 210: 67.84
+	Hs
		625400 ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80		CDK2_HUMAN (274-566): 4.84e-82: 260: 17.97
+	Hs
		834140 PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		833874 ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	Hs
		833945 PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86		CLK2_HUMAN (60-227): 1.39e-63: 218: 32.54
+	At
		789607 DR111_ARATH (443-558): 2.84e-17: 85.9: 42.24		MPK4_ARATH (82-401): 4.37e-78: 252: 15.24
+	Hs
		942761 RBM23_HUMAN (113-300): 2.1e-16: 83.6: 26.60		SRPK2_HUMAN (297-566): 8.12e-72: 244: 57.69
+	Hs
		834041 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Zm
		43418 A0A1D6PK18_MAIZE (36-202): 9.64e-29: 122: 20.44		B6TES5_MAIZE (75-258): 1.12e-50: 180: 20.75
+	Hs
		833736 RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78		CLK1_HUMAN (405-566): 8.71e-11: 66.2: 26.01
+	At
		789605 DR111_ARATH (443-558): 2.84e-17: 85.9: 42.24		MPK1_ARATH (57-258): 5.52e-49: 175: 19.62
+	Hs
		647646 CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50		MK03_HUMAN (65-267): 6e-45: 165: 21.60
+	Hs
		834030 ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97
+	Hs
		834096 PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86		CLK3_HUMAN (396-565): 4.23e-12: 70.9: 25.97