HitPredict

Interactor 1: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Interactor 2: UB2J1 (Q9Y385)
Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)
Gene: UBE2J1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1024 Hs			1 318
+	Hs
		919895 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		849478 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		895943 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		851904 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2E1_HUMAN (1-156): 1.67e-64: 203: 28.30
+	Hs
		1231681 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2J2_HUMAN (1-150): 3.16e-63: 202: 39.87
+	Hs
		1282362 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2E3_HUMAN (2-156): 9.16e-63: 199: 26.58
+	Hs
		1297377 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2E2_HUMAN (2-156): 2.19e-62: 198: 27.22
+	Hs
		829082 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UBE2A_HUMAN (7-154): 3.69e-61: 193: 21.85
+	Hs
		927786 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UBE2B_HUMAN (7-154): 6.08e-60: 190: 22.52
+	Hs
		891446 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2G2_HUMAN (7-142): 5.84e-58: 185: 26.00
+	Hs
		908271 HERC5_HUMAN (1-1024): 0: 1123: 100.00		UB2G1_HUMAN (15-148): 2.26e-56: 182: 25.83
+	Hs
		919710 UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		849311 UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		895780 UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		919860 WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		849444 WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		851806 UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37		UB2E1_HUMAN (1-156): 1.67e-64: 203: 28.30
+	Hs
		895910 WWP1_HUMAN (588-1024): 8.35e-169: 520: 21.93		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		125262 WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		125263 WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02		UB2E1_HUMAN (1-156): 1.67e-64: 203: 28.30