HitPredict

Interactor 1: SETD7 (Q8WTS6)
Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)
Gene: SETD7

Interactor 2: SETD7 (Q8WTS6)
Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)
Gene: SETD7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

The method score is based on:

Property	Details
Experiments	24101509, 21245319
Identification Methods	enzymatic study, methyltransferase assay
Interaction Type	direct interaction, methylation reaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	MORN~MORN, MORN~SET, SET~SET, SET~SET7_N, SET7_N~SET7_N
Common GO terms	GO:0002039 - p53 binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome and 13 others more... GO:0005730 - nucleolus GO:0006282 - regulation of DNA repair GO:0006325 - chromatin organization GO:0006974 - DNA damage response GO:0016279 - protein-lysine N-methyltransferase activity GO:0018026 - peptidyl-lysine monomethylation GO:0018027 - peptidyl-lysine dimethylation GO:0042054 - histone methyltransferase activity GO:0045471 - response to ethanol GO:0045893 - positive regulation of DNA-templated transcription GO:0070828 - heterochromatin organization GO:0140938 - histone H3 methyltransferase activity GO:0140945 - histone H3K4 monomethyltransferase activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	366
Hs

1	366

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Last updated: 11Aug2025