HitPredict

Interactor 1: LEF1 (Q9UJU2)
Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)
Gene: LEF1

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9843967
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 399 Hs			1 456
+	Hs
		1301007 CIC_HUMAN (63-393): 8.23e-35: 138: 16.47		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Mm
		818680 SOX2_MOUSE (261-396): 3.98e-36: 136: 21.32		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Mm
		888064 Q60I23_MOUSE (261-396): 3.67e-36: 136: 21.32		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		818624 SOX2_HUMAN (272-396): 2.2e-32: 126: 22.40		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1301006 CIC_HUMAN (63-393): 8.23e-35: 138: 16.47		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Mm
		1142023 Q60I23_MOUSE (261-396): 3.67e-36: 136: 21.32		RUVB2_MOUSE (2-455): 0: 651: 42.76
+	Mm
		818777 SOX2_MOUSE (261-396): 3.98e-36: 136: 21.32		RUVB2_MOUSE (2-455): 0: 651: 42.76
+	Hs
		818621 SOX2_HUMAN (272-396): 2.2e-32: 126: 22.40		RUVB2_HUMAN (2-455): 0: 651: 42.76