HitPredict

Interactor 1: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21081666
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 1122
+	Hs
		1318188 TBL1R_HUMAN (134-466): 1.2e-76: 251: 14.57		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1038823 PRP19_HUMAN (1-504): 2.85e-165: 479: 100.00		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		880817 TBL1R_HUMAN (134-466): 1.2e-76: 251: 14.57		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		903610 WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1260185 TBL1R_HUMAN (134-466): 1.2e-76: 251: 14.57		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		1260173 FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		1038686 TBL1R_HUMAN (134-466): 1.2e-76: 251: 14.57		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1270423 TBL1R_HUMAN (134-466): 1.2e-76: 251: 14.57		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		1270358 FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		177377 TBL1R_HUMAN (134-466): 1.2e-76: 251: 14.57		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Dm
		1182201 EBI_DROME (109-424): 6.09e-70: 238: 18.37		Q7KTS4_DROME (681-1119): 6.09e-143: 439: 22.08
+	Dm
		1279322 EBI_DROME (109-424): 6.09e-70: 238: 18.37		Q9VNC2_DROME (681-1119): 1.04e-141: 435: 21.86
+	Hs
		1270370 SNR40_HUMAN (298-504): 7e-58: 197: 21.91		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		903202 WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		903404 WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		177249 WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Dm
		1212080 EBI_DROME (109-424): 6.09e-70: 238: 18.37		Q8I9J6_DROME (51-611): 2.35e-11: 70.5: 20.10