HitPredict

Interactor 1: P3C2B (O00750)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)
Gene: PIK3C2B

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	15778465, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1634 Hs			1 248
+	Hs
		135774 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		135776 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		135766 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		135769 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		135773 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		135778 P3C2B_HUMAN (1-1634): 0: 1964: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		128814 P3C2A_HUMAN (89-1626): 0: 1241: 45.92		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		128836 P3C2A_HUMAN (89-1626): 0: 1241: 45.92		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		128838 P3C2A_HUMAN (89-1626): 0: 1241: 45.92		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		128810 P3C2A_HUMAN (89-1626): 0: 1241: 45.92		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		128813 P3C2A_HUMAN (89-1626): 0: 1241: 45.92		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		128834 P3C2A_HUMAN (89-1626): 0: 1241: 45.92		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		128844 P3C2A_HUMAN (89-1626): 0: 1241: 45.92		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Dm
		664613 Q7K3H0_DROME (177-1631): 0: 1071: 35.21		1433Z_DROME (1-245): 4.71e-99: 290: 66.12
+	Hs
		646704 PK3CB_HUMAN (294-1341): 0: 796: 24.71		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		787214 PK3CA_HUMAN (307-1344): 0: 804: 25.46		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Mm
		787345 PK3CA_MOUSE (307-1344): 0: 797: 25.36		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Hs
		647121 PK3C3_HUMAN (624-1341): 3e-155: 498: 18.63		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		904645 Q4LE69_HUMAN (696-1343): 2.04e-146: 500: 19.16		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		982077 Q4LE69_HUMAN (696-1343): 2.04e-146: 500: 19.16		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20