Protein: RCL1
RNA 3'-terminal phosphate cyclase-like protein

Gene: RCL1
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q9Y2P8

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000479 - endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0004521 - RNA endonuclease activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1131002

BMS1
Ribosome biogenesis protein BMS1 homolog

4

2

Small-scale

0.691

High

373549

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.584

High

998969

H31
Histone H3.1

2

1

High-throughput

0.584

High

397267

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

898033

CDK9
Cyclin-dependent kinase 9

2

0

High-throughput

0.559

High

1161767

IF16
Gamma-interferon-inducible protein 16

2

0

High-throughput

0.559

High

1346995

SNIP1
Smad nuclear-interacting protein 1

2

0

Small-scale

0.559

High

1063717

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.553

High

634700

LMNB1
Lamin-B1

1

1

High-throughput

0.536

High

648391

USF1
Upstream stimulatory factor 1

1

4

High-throughput

0.536

High

895508

SPB9
Serpin B9

1

2

High-throughput

0.536

High

1408426

SH3G3
Endophilin-A3

2

1

High-throughput

0.521

High

127210

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.513

High

251675

CCNT1
Cyclin-T1

1

0

High-throughput

0.513

High

447598

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

1065505

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1436082

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

1490473

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

0

High-throughput

0.513

High

1153236

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

2

High-throughput

0.489

High

173586

XPO1
Exportin-1

1

3

High-throughput

0.479

High

285531

EED
Polycomb protein EED

1

1

High-throughput

0.479

High

298466

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.479

High

316184

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

590074

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

644138

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.479

High

675734

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.479

High

696911

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

769559

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

809926

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.479

High

979357

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

1004429

NOP14
Nucleolar protein 14

1

1

High-throughput

0.479

High

1100562

TIF1B
Transcription intermediary factor 1-beta

1

1

Small-scale

0.479

High

1106141

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.479

High

1336651

PAPD5
Terminal nucleotidyltransferase 4B

1

1

High-throughput

0.479

High

1356419

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

1

High-throughput

0.479

High

1361263

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1367635

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1393841

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1402349

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

1404850

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

1452262

AATF
Protein AATF

1

1

High-throughput

0.479

High

1452372

DDX56
Probable ATP-dependent RNA helicase DDX56

1

1

High-throughput

0.479

High

1459372

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

129573

MEN1
Menin

1

0

High-throughput

0.458

High

212352

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

274814

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

476878

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.458

High

542291

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.458

High

607678

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

0

High-throughput

0.458

High

620667

NUCL
Nucleolin

1

0

High-throughput

0.458

High

799600

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

879636

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

905310

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

908483

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.458

High

1107354

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1137597

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1241304

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.458

High

1277973

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

1294132

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.458

High

1313549

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1329144

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

0

High-throughput

0.458

High

1352847

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1360535

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.458

High

1384911

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1385655

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1400712

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.458

High

1405405

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

1410166

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

0

High-throughput

0.458

High

1417353

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.458

High

1430038

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.458

High

1447467

ANLN
Anillin

1

0

High-throughput

0.458

High

1448253

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1454365

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1490855

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

430534

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

971317

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1124764

SRC8
Src substrate cortactin

1

1

High-throughput

0.437

High

1215906

RC3H1
Roquin-1

1

1

High-throughput

0.437

High

1256174

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1434276

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1438091

RC3H2
Roquin-2

1

1

High-throughput

0.437

High

1454779

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

1460318

XPO7
Exportin-7

1

3

High-throughput

0.437

High

1461713

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

442836

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

1130537

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

109164

G4U4J3
Terminal nucleotidyltransferase 4B

1

1

High-throughput

0.407

High

1102386

GRB10
Growth factor receptor-bound protein 10

2

0

High-throughput

0.298

High

1242432

RHGBA
Rho GTPase-activating protein 11A

2

0

High-throughput

0.298

High

329395

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

1243703

EMB
Embigin

1

0

High-throughput

0.279

Low

1244490

ULK3
Serine/threonine-protein kinase ULK3

1

0

High-throughput

0.279

Low

1339920

TTL
Tubulin--tyrosine ligase

1

0

High-throughput

0.279

Low

1367829

TFG
Protein TFG

1

0

High-throughput

0.279

Low

1453499

ARHGC
Rho guanine nucleotide exchange factor 12

1

0

High-throughput

0.279

Low

1460613

KLH21
Kelch-like protein 21

1

0

High-throughput

0.279

Low

158011

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

294553

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

320162

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

346528

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

401727

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

1024946

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

1126216

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1290835

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

1414024

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.249

Low

1431351

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

1214224

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1253213

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025