HitPredict

Interactor 1: YIQ4 (Q9UT39)
Uncharacterized WD repeat-containing protein C824.04
Gene: SPAC824.04

Interactor 2: PFS2 (Q9UTN4)
Polyadenylation factor subunit 2
Gene: PFS2

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	24945319, 14617822
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005829 - cytosol GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex GO:0180010 - co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 341 Sp			1 509
+	Hs
		1281292 FBXW7_HUMAN (3-330): 9.69e-71: 235: 13.72		FBXW7_HUMAN (191-504): 4.73e-52: 189: 14.15
+	Mm
		925836 LIS1_MOUSE (179-337): 9.9e-29: 116: 10.69		LIS1_MOUSE (160-468): 3e-71: 234: 21.59
+	Hs
		792935 LIS1_HUMAN (179-337): 1.17e-28: 116: 10.69		LIS1_HUMAN (160-468): 4.63e-71: 233: 21.59
+	Hs
		903418 FBXW7_HUMAN (3-330): 9.69e-71: 235: 13.72		WDR5_HUMAN (332-496): 1.36e-20: 94.6: 12.28
+	Sc
		732673 SWD2_YEAST (6-336): 2.24e-80: 249: 29.43		PFS2_YEAST (3-191): 1.78e-11: 68: 14.80
+	Hs
		863508 FBXW7_HUMAN (3-330): 9.69e-71: 235: 13.72		COPA_HUMAN (167-403): 1.78e-15: 81.6: 24.39
+	Hs
		1240442 POC1B_HUMAN (102-337): 1.34e-52: 181: 15.19		POC1A_HUMAN (2-153): 1.26e-31: 127: 10.53
+	Hs
		1346954 NLE1_HUMAN (55-337): 2.66e-56: 191: 10.46		NLE1_HUMAN (324-505): 3.04e-20: 95.3: 12.06
+	Hs
		903551 NLE1_HUMAN (55-337): 2.66e-56: 191: 10.46		WDR5_HUMAN (332-496): 1.36e-20: 94.6: 12.28
+	Hs
		921751 NLE1_HUMAN (55-337): 2.66e-56: 191: 10.46		GBB2_HUMAN (57-151): 3.15e-11: 66.6: 20.00
+	Hs
		792949 LIS1_HUMAN (179-337): 1.17e-28: 116: 10.69		WDR5_HUMAN (332-496): 1.36e-20: 94.6: 12.28
+	Hs
		903428 SNR40_HUMAN (181-338): 1.52e-26: 109: 11.25		WDR5_HUMAN (332-496): 1.36e-20: 94.6: 12.28
+	Hs
		196984 PRP4_HUMAN (205-340): 2.77e-24: 105: 13.87		WDR5_HUMAN (332-496): 1.36e-20: 94.6: 12.28
+	Dm
		1358859 FBXW7_DROME (202-338): 6e-25: 107: 13.77		WDS_DROME (347-496): 2.72e-19: 91.1: 13.46
+	Hs
		282843 LIS1_HUMAN (179-337): 1.17e-28: 116: 10.69		CIAO1_HUMAN (170-396): 2.47e-15: 79: 25.53
+	Sp
		999842 TUP12_SCHPO (180-340): 2.02e-26: 111: 10.56		TUP11_SCHPO (3-115): 1.89e-15: 81.1: 10.35
+	Hs
		793026 LIS1_HUMAN (179-337): 1.17e-28: 116: 10.69		KTNB1_HUMAN (84-259): 2.91e-10: 64.7: 23.16
+	Hs
		197071 SNR40_HUMAN (181-338): 1.52e-26: 109: 11.25		PRP4_HUMAN (322-469): 7.51e-11: 66.4: 10.49
+	Hs
		196910 PRP4_HUMAN (205-340): 2.77e-24: 105: 13.87		PRP4_HUMAN (322-469): 7.51e-11: 66.4: 10.49