HitPredict

Interactor 1: UBE2C (O00762)
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Gene: UBE2C

Interactor 2: TRI23 (P36406)
E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)
Gene: TRIM23

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20724660
Identification Methods	enzymatic study
Interaction Type	ubiquitination reaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 179 Hs			1 574
+	Hs
		734581 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00
+	Hs
		734819 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00
+	Hs
		734563 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00
+	Hs
		734733 UB2E2_HUMAN (2-175): 2.69e-78: 233: 33.52		TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00
+	Hs
		734570 UB2D3_HUMAN (31-176): 2.12e-78: 231: 34.93		TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00
+	Hs
		734564 UB2E1_HUMAN (5-175): 5.46e-75: 224: 32.18		TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00
+	Hs
		734571 UBE2N_HUMAN (33-161): 1.73e-29: 107: 44.96		TRI23_HUMAN (1-574): 1.73e-139: 418: 100.00
+	Hs
		895769 UB2D3_HUMAN (31-176): 2.12e-78: 231: 34.93		ARF6_HUMAN (399-567): 3.05e-87: 269: 54.44
+	Hs
		1356055 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51
+	Hs
		919896 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51
+	Hs
		1151762 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		Q6GX22_HUMAN (23-400): 6.72e-69: 237: 19.60
+	Hs
		849480 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51
+	Hs
		1297378 UB2E2_HUMAN (2-175): 2.69e-78: 233: 33.52		TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51
+	Hs
		895945 UB2D3_HUMAN (31-176): 2.12e-78: 231: 34.93		TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51
+	Hs
		1282363 UB2E3_HUMAN (6-175): 6.95e-77: 230: 34.71		TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51
+	Hs
		851905 UB2E1_HUMAN (5-175): 5.46e-75: 224: 32.18		TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51
+	Hs
		896562 UBE2N_HUMAN (33-161): 1.73e-29: 107: 44.96		TRIM1_HUMAN (21-400): 5.38e-69: 238: 19.51
+	Hs
		896464 UBE2N_HUMAN (33-161): 1.73e-29: 107: 44.96		Q6GX22_HUMAN (23-400): 6.72e-69: 237: 19.60