HitPredict

Interactor 1: SMUF1 (Q9V853)
E3 ubiquitin-protein ligase Smurf1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Smurf1) (Lethal with a checkpoint kinase protein) (SMAD ubiquitination regulatory factor 1 homolog) (DSmurf)
Gene: Smurf

Interactor 2: Q9VVJ5 (Q9VVJ5)
Nedd4 family interacting protein (SD09769p)
Gene: Ndfip

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20966964
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1061 Dm			1 267
+	Hs
		1299617 NED4L_HUMAN (9-1059): 0: 718: 27.34		NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32
+	Hs
		1299647 NED4L_HUMAN (9-1059): 0: 718: 27.34		NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05
+	Mm
		93279 E9PXB7_MOUSE (180-1059): 0: 646: 28.89		NFIP1_MOUSE (150-267): 2.34e-57: 184: 42.15
+	Hs
		808249 NEDD4_HUMAN (83-1059): 0: 640: 25.65		NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32
+	Hs
		808291 NEDD4_HUMAN (83-1059): 0: 640: 25.65		NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05
+	Dm
		1374786 NEDD4_DROME (9-561): 1.24e-40: 164: 15.15		Q9VVJ5_DROME (1-267): 3.24e-164: 457: 100.00
+	Dm
		1374794 SUDX_DROME (10-547): 2.68e-30: 131: 12.00		Q9VVJ5_DROME (1-267): 3.24e-164: 457: 100.00
+	Rn
		1137274 NEDD4_RAT (11-414): 6.69e-38: 155: 18.06		NFIP1_RAT (150-267): 2.66e-57: 184: 41.32
+	Hs
		1311857 WWP1_HUMAN (9-593): 2.45e-37: 154: 17.09		NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32
+	Mm
		808368 NEDD4_MOUSE (11-389): 1.57e-36: 151: 19.66		NFIP1_MOUSE (150-267): 2.34e-57: 184: 42.15
+	Hs
		1327920 WWP1_HUMAN (9-593): 2.45e-37: 154: 17.09		NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05
+	Hs
		1311860 SMUF1_HUMAN (7-362): 6e-36: 148: 25.73		NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32
+	Hs
		1294848 ITCH_HUMAN (12-550): 4.3e-27: 121: 12.16		NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32
+	Hs
		1294871 ITCH_HUMAN (12-550): 4.3e-27: 121: 12.16		NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05
+	Mm
		1208047 ITCH_MOUSE (12-550): 8.56e-22: 104: 12.20		NFIP1_MOUSE (150-267): 2.34e-57: 184: 42.15
+	Hs
		125686 WWP2_HUMAN (7-547): 9.03e-20: 97.5: 13.43		NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32
+	Hs
		125746 WWP2_HUMAN (7-547): 9.03e-20: 97.5: 13.43		NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05