Protein: GEMI6
Gem-associated protein 6 (Gemin-6) (SIP2)

Gene: GEMI6, GEMIN6
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q8WXD5

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000387 - spliceosomal snRNP assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1360306

GEMI7
Gem-associated protein 7

11

1

Small-scale

0.984

High

1360307

GEMI8
Gem-associated protein 8

3

0

High-throughput

0.816

High

973996

RUXF
Small nuclear ribonucleoprotein F

6

3

Small-scale

0.733

High

1160528

SMN
Survival motor neuron protein

7

0

Small-scale

0.718

High

1360316

STRAP
Serine-threonine kinase receptor-associated protein

6

0

Small-scale

0.703

High

574394

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

4

1

Small-scale

0.694

High

973777

RUXE
Small nuclear ribonucleoprotein E

5

0

Small-scale

0.684

High

167109

GEMI2
Gem-associated protein 2

5

0

Small-scale

0.684

High

1360309

DDX20
Probable ATP-dependent RNA helicase DDX20

5

0

Small-scale

0.684

High

472927

RU17
U1 small nuclear ribonucleoprotein 70 kDa

5

0

High-throughput

0.682

High

1360308

SPN90
NCK-interacting protein with SH3 domain

4

0

High-throughput

0.667

High

944528

GEMI4
Gem-associated protein 4

4

0

Small-scale

0.664

High

974170

RUXG
Small nuclear ribonucleoprotein G

3

6

Small-scale

0.660

High

974624

SMD2
Small nuclear ribonucleoprotein Sm D2

3

0

Small-scale

0.632

High

775226

FUS
RNA-binding protein FUS

2

0

High-throughput

0.585

High

1353020

GEMI5
Gem-associated protein 5

2

0

Small-scale

0.585

High

1360292

ACO11
Acyl-coenzyme A thioesterase 11

2

0

High-throughput

0.580

High

1360295

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

129288

MEN1
Menin

2

0

High-throughput

0.559

High

1360303

P2Y12
P2Y purinoceptor 12

2

2

High-throughput

0.558

High

911939

JAK3
Tyrosine-protein kinase JAK3

1

1

High-throughput

0.536

High

991218

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

1

High-throughput

0.536

High

1360300

TBD2A
TBC1 domain family member 2A

1

1

High-throughput

0.536

High

1360312

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

5

High-throughput

0.536

High

974433

SMD1
Small nuclear ribonucleoprotein Sm D1

1

4

Small-scale

0.527

High

377038

NEU2
Vasopressin-neurophysin 2-copeptin

1

0

High-throughput

0.513

High

478135

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480244

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

540059

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.513

High

1010452

GPSM2
G-protein-signaling modulator 2

1

0

High-throughput

0.513

High

1187896

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.513

High

1308466

VRK3
Serine/threonine-protein kinase VRK3

1

0

High-throughput

0.513

High

1325062

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.513

High

1360294

FGF14
Fibroblast growth factor 14

1

0

High-throughput

0.513

High

1360297

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1360299

SLX1
Structure-specific endonuclease subunit SLX1

1

0

High-throughput

0.513

High

1360317

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.513

High

1360310

NUFP1
FMR1-interacting protein NUFIP1

1

0

Small-scale

0.504

High

974798

SMD3
Small nuclear ribonucleoprotein Sm D3

1

4

Small-scale

0.501

High

1142120

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

178039

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

5

High-throughput

0.479

High

1360315

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

4

High-throughput

0.479

High

1360318

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

4

High-throughput

0.479

High

363633

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

521396

ARAF
Serine/threonine-protein kinase A-Raf

1

0

High-throughput

0.458

High

762474

PROF2
Profilin-2

1

0

High-throughput

0.458

High

970848

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1113849

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1360293

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1360296

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1360304

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1360305

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1360311

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1360314

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

71599

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

6

High-throughput

0.445

High

171533

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.445

High

166367

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

388262

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

1316950

FAM9B
Protein FAM9B

1

0

High-throughput

0.426

High

1240912

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.407

High

1243637

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.407

High

1360301

RAB17
Ras-related protein Rab-17

2

0

High-throughput

0.318

High

1360298

RSLBB
Ras-like protein family member 11B

2

0

High-throughput

0.316

High

318521

TOX4
TOX high mobility group box family member 4

1

0

High-throughput

0.299

High

567041

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

683297

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.279

Low

1179778

TMM44
Transmembrane protein 44

1

0

High-throughput

0.279

Low

1291642

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1330722

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.279

Low

1360302

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1360319

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

124421

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

936095

PAR2
Proteinase-activated receptor 2

1

0

High-throughput

0.249

Low

50640

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

754077

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.232

Low

1293876

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

1360313

ANGL2
Angiopoietin-related protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025