HitPredict

Interactor 1: RING1 (Q9VB08)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RING1) (Sex comb extra protein) (dRING protein) (dRING1)
Gene: Sce

Interactor 2: Q9VV77 (Q9VV77)
Lethal (3) 73Ah, isoform A (Lethal (3) 73Ah, isoform B) (RE11339p)
Gene: l(3)73Ah

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	25242320, 36070387
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding GO:0035102 - PRC1 complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 435 Dm			1 222
+	Dm
		728805 RING1_DROME (1-435): 5e-109: 330: 100.00		PSC_DROME (2-218): 1.16e-48: 172: 34.69
+	Dm
		627169 RING1_DROME (1-435): 5e-109: 330: 100.00		SUZ2_DROME (7-218): 1.08e-42: 155: 24.55
+	Hs
		987977 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		PCGF3_HUMAN (1-222): 1.25e-61: 194: 54.55
+	Mm
		193404 RING1_MOUSE (9-434): 2.32e-80: 255: 35.68		BMI1_MOUSE (2-219): 2.13e-58: 188: 37.23
+	Hs
		717742 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		BMI1_HUMAN (2-219): 9.77e-59: 189: 36.91
+	Hs
		988039 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		R4GMX3_HUMAN (2-219): 3e-57: 189: 36.91
+	Hs
		718393 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		PCGF2_HUMAN (2-219): 1.09e-55: 182: 35.17
+	Mm
		193403 RING1_MOUSE (9-434): 2.32e-80: 255: 35.68		PCGF2_MOUSE (2-219): 1.35e-52: 174: 35.59
+	Hs
		988015 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		PCGF1_HUMAN (2-219): 3.55e-53: 173: 39.82
+	Hs
		987986 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		PCGF5_HUMAN (2-222): 1.99e-47: 158: 37.01
+	Hs
		988016 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		PCGF6_HUMAN (2-216): 2.25e-44: 153: 38.12
+	Mm
		193415 RING1_MOUSE (9-434): 2.32e-80: 255: 35.68		RING2_MOUSE (1-124): 1.56e-31: 119: 21.60
+	Mm
		193402 RING1_MOUSE (9-434): 2.32e-80: 255: 35.68		RING1_MOUSE (2-124): 3.14e-30: 117: 22.58
+	Hs
		988012 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		RING2_HUMAN (1-124): 1.78e-31: 119: 21.60
+	Hs
		717489 PCGF2_HUMAN (29-363): 3.49e-50: 175: 12.57		BMI1_HUMAN (2-219): 9.77e-59: 189: 36.91
+	Hs
		987956 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		RING1_HUMAN (2-124): 2.4e-29: 114: 22.58
+	Hs
		536748 BRCA1_HUMAN (31-391): 1.09e-52: 192: 13.68		TRI27_HUMAN (1-200): 1.75e-30: 119: 16.74
+	At
		1341400 DRIP1_ARATH (31-388): 1.25e-57: 196: 16.22		DRIP1_ARATH (1-125): 1.74e-26: 107: 23.19