Protein: CHTOP
Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)

Gene: CHTOP
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q9Y3Y2

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0001701 - in utero embryonic development
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1118204

DX39B
Spliceosome RNA helicase DDX39B

13

2

Small-scale

0.760

High

1407973

ANM1
Protein arginine N-methyltransferase 1

7

4

Small-scale

0.744

High

123196

DX39A
ATP-dependent RNA helicase DDX39A

6

2

High-throughput

0.728

High

1015341

ERH
Enhancer of rudimentary homolog

11

0

Small-scale

0.724

High

1400772

UIF
UAP56-interacting factor

6

0

High-throughput

0.699

High

1447764

ANM8
Protein arginine N-methyltransferase 8

4

3

High-throughput

0.691

High

1290204

THOC4
THO complex subunit 4

3

1

Small-scale

0.662

High

1006819

SRPK2
SRSF protein kinase 2

2

3

High-throughput

0.649

High

1160628

SMN
Survival motor neuron protein

3

0

High-throughput

0.646

High

1219159

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

3

0

High-throughput

0.646

High

478271

SNRPA
U1 small nuclear ribonucleoprotein A

3

0

High-throughput

0.636

High

1131863

LBR
Delta(14)-sterol reductase LBR

3

0

High-throughput

0.634

High

1402654

SRPK1
SRSF protein kinase 1

2

3

High-throughput

0.628

High

1391003

THOC1
THO complex subunit 1

3

0

Small-scale

0.626

High

1198707

NCBP3
Nuclear cap-binding protein subunit 3

3

0

High-throughput

0.622

High

1117231

THOC5
THO complex subunit 5

3

0

Small-scale

0.622

High

162744

ANM5
Protein arginine N-methyltransferase 5

2

4

Small-scale

0.611

High

1410414

MEP50
Methylosome protein WDR77

2

3

Small-scale

0.611

High

1023306

RBM3
RNA-binding protein 3

2

1

High-throughput

0.606

High

1013192

SARNP
SAP domain-containing ribonucleoprotein

2

0

High-throughput

0.602

High

807633

IF4A3
Eukaryotic initiation factor 4A-III

2

0

High-throughput

0.585

High

1127280

RBM39
RNA-binding protein 39

2

0

High-throughput

0.585

High

260646

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.584

High

373588

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

1067871

EP300
Histone acetyltransferase p300

2

4

High-throughput

0.584

High

1448911

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

2

0

High-throughput

0.580

High

1041873

CENPC
Centromere protein C

2

0

High-throughput

0.576

High

1058376

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

High-throughput

0.576

High

1341053

THOC2
THO complex subunit 2

2

0

Small-scale

0.576

High

1461765

CIZ1
Cip1-interacting zinc finger protein

2

0

High-throughput

0.576

High

1361713

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

2

1

High-throughput

0.574

High

397300

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

766047

BMI1
Polycomb complex protein BMI-1

2

2

High-throughput

0.571

High

1458775

NXF1
Nuclear RNA export factor 1

1

0

Small-scale

0.561

High

1237934

PHLB3
Pleckstrin homology-like domain family B member 3

2

1

High-throughput

0.553

High

1462458

SRPK3
SRSF protein kinase 3

2

3

High-throughput

0.549

High

1491305

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

1

High-throughput

0.549

High

273459

KDM4A
Lysine-specific demethylase 4A

1

1

High-throughput

0.536

High

471344

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.536

High

481420

HMGB1
High mobility group protein B1

1

4

High-throughput

0.536

High

788278

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

889845

CLK3
Dual specificity protein kinase CLK3

1

2

High-throughput

0.536

High

1044400

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.536

High

1065511

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

1109253

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

2

High-throughput

0.536

High

1116168

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.536

High

1270689

COX15
Heme A synthase COX15

1

1

High-throughput

0.536

High

1290857

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.536

High

1332646

ZN579
Zinc finger protein 579

1

1

High-throughput

0.536

High

1404931

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.536

High

1406670

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

1452581

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.536

High

1459584

KDM5B
Lysine-specific demethylase 5B

1

1

High-throughput

0.536

High

698396

MAP4
Microtubule-associated protein 4

1

1

High-throughput

0.515

High

273026

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

339016

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.513

High

443570

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.513

High

480363

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

542296

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

574530

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

898904

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.513

High

974092

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

1149236

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

1151243

OASL
2'-5'-oligoadenylate synthase-like protein

1

0

High-throughput

0.513

High

1160355

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1233226

THOC7
THO complex subunit 7

1

0

High-throughput

0.513

High

1245443

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.513

High

1360317

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.513

High

1389778

RBM33
RNA-binding protein 33

1

0

High-throughput

0.513

High

1411777

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.513

High

1446874

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

0

High-throughput

0.513

High

1450170

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.513

High

1458751

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.513

High

856442

IF2M
Translation initiation factor IF-2, mitochondrial

1

0

High-throughput

0.493

High

1137605

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

540288

SPTB1
Spectrin beta chain, erythrocytic

1

1

High-throughput

0.489

High

641076

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.489

High

774022

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

1057673

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.489

High

1061569

ACTN3
Alpha-actinin-3

1

1

High-throughput

0.489

High

1247539

POTEE
POTE ankyrin domain family member E

1

1

High-throughput

0.489

High

227721

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

316206

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

406842

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

607261

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

659323

SP100
Nuclear autoantigen Sp-100

1

3

High-throughput

0.479

High

674385

BRD2
Bromodomain-containing protein 2

1

5

High-throughput

0.479

High

685787

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.479

High

854966

RECQ1
ATP-dependent DNA helicase Q1

1

1

High-throughput

0.479

High

872928

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

965362

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

1026604

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1088638

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1133069

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

1141381

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.479

High

1201972

BRDT
Bromodomain testis-specific protein

1

4

High-throughput

0.479

High

1316604

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

1

Small-scale

0.479

High

1367671

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1380283

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

1401466

CIC
Protein capicua homolog

1

1

High-throughput

0.479

High

1402356

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

1404866

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

1417841

PDIP3
Polymerase delta-interacting protein 3

1

1

High-throughput

0.479

High

1429958

BRD8
Bromodomain-containing protein 8

1

1

High-throughput

0.479

High

1430656

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1447875

DDX21
Nucleolar RNA helicase 2

1

2

High-throughput

0.479

High

1459427

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1491302

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

1491303

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

129590

MEN1
Menin

1

0

High-throughput

0.458

High

302680

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

Small-scale

0.458

High

317696

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.458

High

325191

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

473217

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

485538

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

487913

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

538162

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

590110

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

630107

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

664838

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

696949

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

699285

CALX
Calnexin

1

0

High-throughput

0.458

High

755039

H2B1B
Histone H2B type 1-B

1

0

High-throughput

0.458

High

769594

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

786951

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

851714

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

951921

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

961131

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

980592

H4
Histone H4

1

0

High-throughput

0.458

High

984034

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

998995

H31
Histone H3.1

1

0

High-throughput

0.458

High

1024957

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1057064

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.458

High

1107366

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1122206

UBP2L
Ubiquitin-associated protein 2-like

1

0

High-throughput

0.458

High

1155940

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1194487

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1228502

FTM
Protein fantom

1

0

High-throughput

0.458

High

1271935

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1289743

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1352864

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1393869

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1405582

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

1408501

VRK1
Serine/threonine-protein kinase VRK1

1

0

High-throughput

0.458

High

1417538

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1421036

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1447490

ANLN
Anillin

1

0

High-throughput

0.458

High

1451482

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1452269

AATF
Protein AATF

1

0

High-throughput

0.458

High

1454121

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

1461119

NXT1
NTF2-related export protein 1

1

0

Small-scale

0.458

High

1491274

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

430555

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

530648

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

952392

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.445

High

1121763

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.445

High

1148493

SAFB1
Scaffold attachment factor B1

1

1

High-throughput

0.445

High

1398419

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.445

High

1461436

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.445

High

132401

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.437

High

171946

ZN263
Zinc finger protein 263

1

1

Small-scale

0.437

High

720372

UFO
Tyrosine-protein kinase receptor UFO

1

5

High-throughput

0.437

High

761314

RYK
Tyrosine-protein kinase RYK

1

3

High-throughput

0.437

High

932016

EPHB4
Ephrin type-B receptor 4

1

3

High-throughput

0.437

High

1055112

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

5

High-throughput

0.437

High

1088236

MERTK
Tyrosine-protein kinase Mer

1

5

High-throughput

0.437

High

1207852

EPHAA
Ephrin type-A receptor 10

1

4

High-throughput

0.437

High

1220904

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

1227762

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

1349445

POC1B
POC1 centriolar protein homolog B

1

2

High-throughput

0.437

High

1389431

RNF31
E3 ubiquitin-protein ligase RNF31

1

1

High-throughput

0.437

High

1399131

SCLT1
Sodium channel and clathrin linker 1

1

1

High-throughput

0.437

High

1454785

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

1461724

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

697436

DCK
Deoxycytidine kinase

1

0

High-throughput

0.426

High

1119388

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1136765

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.426

High

1209833

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1256775

CCD9B
Coiled-coil domain-containing protein 9B

1

0

High-throughput

0.426

High

1288953

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

1326169

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1420776

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1491304

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.426

High

887373

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

1433254

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.407

High

1179083

RSPO1
R-spondin-1

3

0

High-throughput

0.347

High

165836

TR13B
Tumor necrosis factor receptor superfamily member 13B

2

0

High-throughput

0.328

High

423516

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.322

High

564601

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.288

High

67577

MYH7B
Myosin-7B

1

0

High-throughput

0.279

Low

1097127

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

0

High-throughput

0.279

Low

1116951

AT1A4
Sodium/potassium-transporting ATPase subunit alpha-4

1

0

High-throughput

0.279

Low

1127545

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1205510

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.279

Low

1273921

BHA15
Class A basic helix-loop-helix protein 15

1

0

High-throughput

0.279

Low

1363548

TRIB2
Tribbles homolog 2

1

0

High-throughput

0.279

Low

1452399

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

1490748

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

1490831

KLH20
Kelch-like protein 20

1

0

High-throughput

0.279

Low

1241996

Z585A
Zinc finger protein 585A

1

0

High-throughput

0.269

Low

891369

GSK3A
Glycogen synthase kinase-3 alpha

1

0

High-throughput

0.265

Low

177080

CE290
Centrosomal protein of 290 kDa

1

0

High-throughput

0.249

Low

184343

NPHP1
Nephrocystin-1

1

0

High-throughput

0.249

Low

272572

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

341710

EYA4
Protein phosphatase EYA4

1

0

High-throughput

0.249

Low

353648

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

401751

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

547935

PERE
Eosinophil peroxidase

1

0

High-throughput

0.249

Low

641715

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

0

High-throughput

0.249

Low

730982

1433S
14-3-3 protein sigma

1

0

Small-scale

0.249

Low

971344

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

995915

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1123885

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.249

Low

1135197

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1141094

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1203109

CC178
Coiled-coil domain-containing protein 178

1

0

High-throughput

0.249

Low

1256229

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1332542

POC5
Centrosomal protein POC5

1

0

High-throughput

0.249

Low

1333379

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1338450

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1360134

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.249

Low

1363904

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.249

Low

1418548

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1434311

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

50837

CA226
Uncharacterized protein C1orf226

1

0

High-throughput

0.232

Low

255318

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

1203305

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.232

Low

1211045

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.232

Low

1214231

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1335794

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1400204

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025