HitPredict

Interactor 1: PAK (Q9VI13)
Serine/threonine-protein kinase Pak (EC 2.7.11.1)
Gene: PAK

Interactor 2: Q9VIN1 (Q9VIN1)
Rho-type guanine nucleotide exchange factor, isoform A (Rho-type guanine nucleotide exchange factor, isoform B)
Gene: RtGEF

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0097482 - muscle cell postsynaptic specialization
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 704 Dm			1 687
+	Dm
		115760 PAK_DROME (1-704): 0: 584: 100.00		M9PGB1_DROME (1-627): 1.53e-149: 459: 99.52
+	Dm
		115752 HIPPO_DROME (388-704): 4.65e-122: 380: 36.73		M9PGB1_DROME (1-627): 1.53e-149: 459: 99.52
+	Hs
		166594 DCLK1_HUMAN (22-704): 6.96e-141: 431: 17.07		ARHG2_HUMAN (43-671): 2.66e-83: 285: 12.61
+	Hs
		331058 PAK4_HUMAN (75-698): 1.09e-140: 426: 31.98		ARHG2_HUMAN (43-671): 2.66e-83: 285: 12.61
+	Hs
		1273290 PAK5_HUMAN (75-698): 1.23e-131: 407: 29.19		ARHG2_HUMAN (43-671): 2.66e-83: 285: 12.61
+	Hs
		855832 STK24_HUMAN (424-699): 8.96e-123: 375: 42.81		VAV2_HUMAN (14-512): 1.53e-81: 278: 13.47
+	Mm
		292047 PAK1_MOUSE (5-257): 1.19e-38: 152: 30.68		ARHG7_MOUSE (2-684): 7.01e-136: 422: 32.32
+	Hs
		81635 PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65		B7Z6G2_HUMAN (2-684): 2.51e-140: 429: 31.41
+	Mm
		1142068 PAK3_MOUSE (5-240): 4.45e-34: 139: 28.35		ARHG7_MOUSE (2-684): 7.01e-136: 422: 32.32
+	Rn
		223051 PAK1_RAT (5-257): 1.68e-38: 152: 30.04		ARHG7_RAT (2-684): 1.28e-127: 393: 31.55
+	Hs
		1026158 PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68		ARHG7_HUMAN (2-595): 1.33e-121: 383: 34.02
+	Hs
		1026167 PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68		ARHG6_HUMAN (2-684): 6.99e-119: 375: 28.22
+	Hs
		1026904 PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65		ARHG7_HUMAN (2-595): 1.33e-121: 383: 34.02
+	Hs
		277605 PAK3_HUMAN (5-238): 4.93e-34: 139: 28.57		ARHG7_HUMAN (2-595): 1.33e-121: 383: 34.02
+	Hs
		1026910 PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65		ARHG6_HUMAN (2-684): 6.99e-119: 375: 28.22
+	Ce
		91205 PK1_CAEEL (2-228): 1.52e-44: 170: 31.08		E3W735_CAEEL (3-429): 3.56e-97: 308: 29.75
+	Hs
		1026200 PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68		ARHG2_HUMAN (43-671): 2.66e-83: 285: 12.61
+	Hs
		277606 PAK3_HUMAN (5-238): 4.93e-34: 139: 28.57		ITSN1_HUMAN (7-505): 1.6e-85: 296: 17.21