Protein: PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription 1)

Gene: PTH2, PTRH2
Organism: Homo sapiens
Interactions: 221
UniProt ID: Q9Y3E5

Gene Ontology (top 5):
GO:0004045 - peptidyl-tRNA hydrolase activity
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1431957

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

4

1

High-throughput

0.691

High

174281

ARHGA
Rho guanine nucleotide exchange factor 10

3

1

High-throughput

0.656

High

163370

TR10B
Tumor necrosis factor receptor superfamily member 10B

3

0

High-throughput

0.638

High

1452201

CLC5A
C-type lectin domain family 5 member A

3

0

High-throughput

0.638

High

1491225

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

1

High-throughput

0.618

High

611430

PTN1
Tyrosine-protein phosphatase non-receptor type 1

3

0

High-throughput

0.613

High

1061927

TLE5
TLE family member 5

2

0

Small-scale

0.612

High

483849

CD7
T-cell antigen CD7

2

0

High-throughput

0.602

High

1010130

DLK1
Protein delta homolog 1

2

0

High-throughput

0.585

High

1218508

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

2

0

High-throughput

0.585

High

1382257

CCD47
PAT complex subunit CCDC47

2

0

High-throughput

0.585

High

1366638

AKAP1
A-kinase anchor protein 1, mitochondrial

2

1

High-throughput

0.584

High

1450681

EVA1B
Protein eva-1 homolog B

2

0

High-throughput

0.576

High

926870

VMAT1
Chromaffin granule amine transporter

2

3

High-throughput

0.574

High

397293

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1108310

SQSTM
Sequestosome-1

2

0

High-throughput

0.559

High

1393863

DDRGK
DDRGK domain-containing protein 1

2

0

High-throughput

0.559

High

329037

RTN3
Reticulon-3

1

1

High-throughput

0.536

High

1239076

NIPA3
Magnesium transporter NIPA3

1

1

High-throughput

0.536

High

1429317

S22A4
Solute carrier family 22 member 4

1

3

High-throughput

0.536

High

1051089

FAK1
Focal adhesion kinase 1

1

2

Small-scale

0.515

High

167181

T4S5
Transmembrane 4 L6 family member 5

1

0

High-throughput

0.513

High

226386

SNG1
Synaptogyrin-1

1

0

High-throughput

0.513

High

612023

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

699284

CALX
Calnexin

1

0

High-throughput

0.513

High

720079

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.513

High

951540

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

957044

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

1026291

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1214388

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

1310556

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1329403

TEX29
Testis-expressed protein 29

1

0

High-throughput

0.513

High

1393227

TM169
Transmembrane protein 169

1

0

High-throughput

0.513

High

1402502

SERC2
Serine incorporator 2

1

0

High-throughput

0.513

High

1431643

CHST8
Carbohydrate sulfotransferase 8

1

0

High-throughput

0.513

High

1432964

SRMS
Tyrosine-protein kinase Srms

1

0

High-throughput

0.513

High

1491229

LHPL6
LHFPL tetraspan subfamily member 6 protein

1

0

High-throughput

0.513

High

1491231

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

166074

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

248521

O10H2
Olfactory receptor 10H2

1

1

High-throughput

0.489

High

286602

SG2A1
Mammaglobin-B

1

1

High-throughput

0.489

High

1101451

SG2A2
Mammaglobin-A

1

1

High-throughput

0.489

High

1142226

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1197911

S39AC
Zinc transporter ZIP12

1

1

High-throughput

0.489

High

1406371

GPR21
Probable G-protein coupled receptor 21

1

1

High-throughput

0.489

High

1491226

O10H1
Olfactory receptor 10H1

1

1

High-throughput

0.489

High

1491228

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

130294

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.479

High

159413

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

2

High-throughput

0.479

High

181467

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.479

High

374298

RASN
GTPase NRas

1

1

High-throughput

0.479

High

376130

RASK
GTPase KRas

1

1

High-throughput

0.479

High

466536

RHOC
Rho-related GTP-binding protein RhoC

1

3

High-throughput

0.479

High

906226

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

High-throughput

0.479

High

910264

RND2
Rho-related GTP-binding protein RhoN

1

4

High-throughput

0.479

High

953772

RAC3
Ras-related C3 botulinum toxin substrate 3

1

3

High-throughput

0.479

High

962660

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

978421

RHOB
Rho-related GTP-binding protein RhoB

1

3

High-throughput

0.479

High

1058739

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.479

High

1063208

GOGA3
Golgin subfamily A member 3

1

1

High-throughput

0.479

High

1163885

DUS6
Dual specificity protein phosphatase 6

1

3

High-throughput

0.479

High

1209828

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

1275771

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

High-throughput

0.479

High

1277012

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1312311

MIRO2
Mitochondrial Rho GTPase 2

1

4

High-throughput

0.479

High

1352020

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

1367664

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1408301

DUS9
Dual specificity protein phosphatase 9

1

3

High-throughput

0.479

High

1420389

TRI31
E3 ubiquitin-protein ligase TRIM31

1

1

High-throughput

0.479

High

1446951

RTN4
Reticulon-4

1

1

High-throughput

0.479

High

1448927

DUS22
Dual specificity protein phosphatase 22

1

3

High-throughput

0.479

High

1453367

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

1

High-throughput

0.479

High

1453858

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.479

High

1461934

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1490974

TDRKH
Tudor and KH domain-containing protein

1

1

High-throughput

0.479

High

1491227

SRPRB
Signal recognition particle receptor subunit beta

1

1

High-throughput

0.479

High

125674

LEG9
Galectin-9

1

0

High-throughput

0.458

High

133824

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

135742

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.458

High

158023

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

158365

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

169803

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

High-throughput

0.458

High

175273

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.458

High

223443

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

250175

ADCY9
Adenylate cyclase type 9

1

0

High-throughput

0.458

High

275143

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

281123

TACC1
Transforming acidic coiled-coil-containing protein 1

1

0

High-throughput

0.458

High

291602

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

298836

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.458

High

300067

CBPD
Carboxypeptidase D

1

0

High-throughput

0.458

High

316202

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

320178

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

329608

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.458

High

339624

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.458

High

341493

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.458

High

377796

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

401748

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

418535

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

457794

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

612336

ARF4
ADP-ribosylation factor 4

1

0

High-throughput

0.458

High

617362

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

0

High-throughput

0.458

High

617627

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.458

High

621548

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

631587

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.458

High

635149

ICAL
Calpastatin

1

0

High-throughput

0.458

High

701944

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.458

High

784770

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

820780

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

831694

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

857207

NSF
Vesicle-fusing ATPase

1

0

High-throughput

0.458

High

870020

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

880120

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

0

High-throughput

0.458

High

883373

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

895175

EMD
Emerin

1

0

High-throughput

0.458

High

896337

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.458

High

945333

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.458

High

953205

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

980587

H4
Histone H4

1

0

High-throughput

0.458

High

1031890

LAT1
Large neutral amino acids transporter small subunit 1

1

0

High-throughput

0.458

High

1041388

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1098774

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.458

High

1122596

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

1125748

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1138801

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1162785

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.458

High

1164282

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.458

High

1164635

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1215648

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.458

High

1216569

VP13D
Intermembrane lipid transfer protein VPS13D

1

0

High-throughput

0.458

High

1229789

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1258015

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.458

High

1278155

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

1294034

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.458

High

1330449

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1336700

EHBP1
EH domain-binding protein 1

1

0

High-throughput

0.458

High

1353228

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.458

High

1358407

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.458

High

1365087

UBXN4
UBX domain-containing protein 4

1

0

High-throughput

0.458

High

1382473

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.458

High

1397588

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1402403

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

1402840

TM209
Transmembrane protein 209

1

0

High-throughput

0.458

High

1405968

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.458

High

1412736

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

1414515

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1429154

MFF
Mitochondrial fission factor

1

0

High-throughput

0.458

High

1429592

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.458

High

1432828

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.458

High

1435487

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1436727

GORS2
Golgi reassembly-stacking protein 2

1

0

High-throughput

0.458

High

1438390

VEZA
Vezatin

1

0

High-throughput

0.458

High

1439586

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

0

High-throughput

0.458

High

1446127

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.458

High

1449386

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1450481

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1451764

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1459419

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1461987

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

1490732

FND3A
Fibronectin type-III domain-containing protein 3A

1

0

High-throughput

0.458

High

1490935

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.458

High

1491232

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

104251

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.445

High

303301

S22A5
Organic cation/carnitine transporter 2

1

3

High-throughput

0.445

High

1273834

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.445

High

1431235

S6A17
Sodium-dependent neutral amino acid transporter SLC6A17

1

1

High-throughput

0.445

High

333268

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.437

High

1098215

DUS8
Dual specificity protein phosphatase 8

1

3

High-throughput

0.437

High

1111759

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.437

High

1243263

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

2

High-throughput

0.437

High

1313888

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1433593

RHOJ
Rho-related GTP-binding protein RhoJ

1

4

High-throughput

0.437

High

1437528

WDR41
WD repeat-containing protein 41

1

1

High-throughput

0.437

High

1454274

STIM2
Stromal interaction molecule 2

1

1

High-throughput

0.437

High

190001

MOT7
Monocarboxylate transporter 7

1

0

High-throughput

0.426

High

653676

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1491230

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.426

High

50129

S22AN
Solute carrier family 22 member 23

1

3

High-throughput

0.407

High

96812

E9PB39
Rho guanine nucleotide exchange factor 10

1

1

High-throughput

0.407

High

1309012

S22A9
Organic anion transporter 7

1

3

High-throughput

0.407

High

1328154

TTC9C
Tetratricopeptide repeat protein 9C

1

2

High-throughput

0.407

High

1421376

S39A8
Metal cation symporter ZIP8

1

1

High-throughput

0.407

High

1334096

MINY2
Ubiquitin carboxyl-terminal hydrolase MINDY-2

3

0

High-throughput

0.347

High

1364777

PHYIP
Phytanoyl-CoA hydroxylase-interacting protein

3

0

High-throughput

0.347

High

702872

5HT2C
5-hydroxytryptamine receptor 2C

3

0

High-throughput

0.345

High

252296

TLR5
Toll-like receptor 5

2

0

High-throughput

0.328

High

630201

ACM3
Muscarinic acetylcholine receptor M3

2

0

High-throughput

0.328

High

855401

5HT3A
5-hydroxytryptamine receptor 3A

2

0

High-throughput

0.328

High

1397001

SIG10
Sialic acid-binding Ig-like lectin 10

2

0

High-throughput

0.328

High

1405020

EYA3
Protein phosphatase EYA3

2

0

High-throughput

0.305

High

190567

COPT2
Protein SLC31A2

1

0

High-throughput

0.279

Low

260993

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

328766

VAMP5
Vesicle-associated membrane protein 5

1

0

High-throughput

0.279

Low

376652

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

720643

GRPR
Gastrin-releasing peptide receptor

1

0

High-throughput

0.279

Low

1108421

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.279

Low

1233179

ISM2
Isthmin-2

1

0

High-throughput

0.279

Low

1308314

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.279

Low

1389636

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

1399818

TECTB
Beta-tectorin

1

0

High-throughput

0.279

Low

1428182

YIPF3
Protein YIPF3

1

0

High-throughput

0.279

Low

1431022

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

294572

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

473212

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.249

Low

566884

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

590103

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

769587

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

965360

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1005274

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1097645

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.249

Low

1120846

DSG2
Desmoglein-2

1

0

High-throughput

0.249

Low

1249355

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1256220

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1288307

LYRIC
Protein LYRIC

1

0

High-throughput

0.249

Low

1294528

VRK2
Serine/threonine-protein kinase VRK2

1

0

High-throughput

0.249

Low

1308411

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

0

High-throughput

0.249

Low

1327291

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1406684

COCA1

1

0

High-throughput

0.249

Low

1431300

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.249

Low

1293940

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

1401559

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025