HitPredict - High confidence protein-protein interactions

Interactor 1: TANK (Q92844)
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)
Gene: TANK

Interactor 2: TANK (Q92844)
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)
Gene: TANK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	26779844, 30561431, 10490605, 17568778, 14743216
Identification Methods	unspecified method, affinity chromatography technology, pull down, virotrap, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response GO:0007165 - signal transduction GO:0008270 - zinc ion binding and 16 others more... GO:0010804 - negative regulation of tumor necrosis factor-mediated signaling pathway GO:0031625 - ubiquitin protein ligase binding GO:0032481 - positive regulation of type I interferon production GO:0032991 - protein-containing complex GO:0035800 - deubiquitinase activator activity GO:0043124 - negative regulation of canonical NF-kappaB signal transduction GO:0051607 - defense response to virus GO:0060090 - molecular adaptor activity GO:0060337 - type I interferon-mediated signaling pathway GO:0071347 - cellular response to interleukin-1 GO:0071356 - cellular response to tumor necrosis factor GO:0071479 - cellular response to ionizing radiation GO:0140678 - molecular function inhibitor activity GO:1902554 - serine/threonine protein kinase complex GO:1903003 - positive regulation of protein deubiquitination GO:2000158 - positive regulation of ubiquitin-specific protease activity
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	425
Hs

1	425

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Last updated: 11Aug2025