Protein: TANK
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)

Gene: TANK
Organism: Mus musculus
Interactions: 18
UniProt ID: P70347

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005829 - cytosol
GO:0006974 - DNA damage response
GO:0008270 - zinc ion binding
GO:0010804 - negative regulation of tumor necrosis factor-mediated signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1000259

TBK1
Serine/threonine-protein kinase TBK1

8

5

Small-scale

0.746

High

312482

NEMO
NF-kappa-B essential modulator

3

1

Small-scale

0.640

High

811900

TRAF2
TNF receptor-associated factor 2

3

9

Small-scale

0.636

High

1000249

TANK
TRAF family member-associated NF-kappa-B activator

2

1

Small-scale

0.584

High

1000250

IRF3
Interferon regulatory factor 3

2

2

Small-scale

0.584

High

1000253

TRAF3
TNF receptor-associated factor 3

2

10

Small-scale

0.584

High

1000254

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

1

Small-scale

0.584

High

811870

TRAF1
TNF receptor-associated factor 1

2

8

Small-scale

0.576

High

312138

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

5

Small-scale

0.479

High

1000256

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.479

High

1000257

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

2

Small-scale

0.479

High

1000258

MAVS
Mitochondrial antiviral-signaling protein

1

1

Small-scale

0.479

High

648044

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.458

High

1000251

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.458

High

1000252

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

0

Small-scale

0.458

High

1000255

RIGI
Antiviral innate immune response receptor RIG-I

1

0

Small-scale

0.458

High

313445

CASP8
Caspase-8

1

1

Small-scale

0.437

High


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Last updated: 11Aug2025