HitPredict

Interactor 1: PCNA (O02115)
Proliferating cell nuclear antigen (PCNA)
Gene: pcn-1

Interactor 2: Q18841 (Q18841)
Replication factor C subunit 1
Gene: rfc-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	12679813, 11778048, 14704431
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AAA~PCNA_C, AAA~PCNA_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 263 Ce			1 839
+	Hs
		517101 PCNA_HUMAN (1-260): 1.5e-109: 318: 48.08		RFC1_HUMAN (4-826): 2.65e-122: 398: 29.60
+	Sc
		550542 PCNA_YEAST (1-260): 3.22e-92: 274: 40.39		RFC1_YEAST (4-832): 9.88e-115: 371: 23.93
+	Hs
		517154 PCNA_HUMAN (1-260): 1.5e-109: 318: 48.08		TERA_HUMAN (94-827): 1.7e-94: 315: 10.14
+	Hs
		517383 PCNA_HUMAN (1-260): 1.5e-109: 318: 48.08		CTF18_HUMAN (11-832): 1.87e-88: 303: 15.11
+	Dm
		572231 PCNA_DROME (1-261): 1.22e-109: 318: 47.89		Q9VX15_DROME (258-617): 7.14e-75: 250: 20.75
+	Dm
		572216 PCNA_DROME (1-261): 1.22e-109: 318: 47.89		Q9VKW3_DROME (269-630): 5.96e-73: 244: 16.09
+	Hs
		517099 PCNA_HUMAN (1-260): 1.5e-109: 318: 48.08		RFC4_HUMAN (239-606): 1.54e-72: 243: 21.05
+	Bt
		985516 PCNA_BOVIN (1-260): 6.06e-110: 319: 47.69		RFC2_BOVIN (246-625): 1.98e-71: 240: 18.59
+	Hs
		517100 PCNA_HUMAN (1-260): 1.5e-109: 318: 48.08		RFC2_HUMAN (256-625): 1.26e-70: 238: 19.07
+	Bt
		1100598 PCNA_BOVIN (1-260): 6.06e-110: 319: 47.69		Q29RS9_BOVIN (248-558): 7.35e-70: 235: 19.87
+	Hs
		517115 PCNA_HUMAN (1-260): 1.5e-109: 318: 48.08		RFC3_HUMAN (279-638): 1.04e-69: 236: 14.57
+	Hs
		517114 PCNA_HUMAN (1-260): 1.5e-109: 318: 48.08		RFC5_HUMAN (260-630): 9.22e-68: 230: 16.89
+	Sc
		550563 PCNA_YEAST (1-260): 3.22e-92: 274: 40.39		CTF18_YEAST (238-831): 1.84e-79: 273: 16.11
+	Sc
		550553 PCNA_YEAST (1-260): 3.22e-92: 274: 40.39		RFC4_YEAST (277-556): 1.17e-72: 243: 22.81
+	Sc
		550554 PCNA_YEAST (1-260): 3.22e-92: 274: 40.39		RFC2_YEAST (260-625): 1.63e-71: 240: 18.57
+	Sc
		550541 PCNA_YEAST (1-260): 3.22e-92: 274: 40.39		RFC3_YEAST (267-608): 1.54e-67: 229: 19.71
+	Hs
		517415 PCNA_HUMAN (1-260): 1.5e-109: 318: 48.08		ATAD5_HUMAN (13-404): 4.18e-46: 181: 20.66
+	Hs
		238255 RAD1_HUMAN (2-261): 7.37e-68: 213: 13.97		RFC4_HUMAN (239-606): 1.54e-72: 243: 21.05
+	Hs
		238259 RAD1_HUMAN (2-261): 7.37e-68: 213: 13.97		RFC3_HUMAN (279-638): 1.04e-69: 236: 14.57
+	Hs
		238258 RAD1_HUMAN (2-261): 7.37e-68: 213: 13.97		RFC5_HUMAN (260-630): 9.22e-68: 230: 16.89