HitPredict

Interactor 1: Q9VTW6 (Q9VTW6)
U6 snRNA-associated Sm-like protein LSm2
Gene: DmelCG10418

Interactor 2: Q9W087 (Q9W087)
U6 snRNA-associated Sm-like protein LSm8
Gene: l(3)neo7

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.884

Property	Details
Experiments	14605208, 37061542, 22036573, unassigned2874
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005688 - U6 snRNP GO:0030532 - small nuclear ribonucleoprotein complex GO:0046540 - U4/U6 x U5 tri-snRNP complex and 1 others more... GO:0071011 - precatalytic spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 95 Dm			1 95
+	Hs
		321440 LSM2_HUMAN (1-95): 1.9e-35: 117: 91.58		LSM8_HUMAN (2-95): 1.25e-33: 113: 69.15
+	Dm
		1369698 Q9VKW8_DROME (1-95): 3.05e-32: 111: 28.57		Q9W087_DROME (1-95): 1.1e-34: 115: 100.00
+	Hs
		321444 LSM4_HUMAN (1-87): 5.83e-30: 105: 31.03		LSM8_HUMAN (2-95): 1.25e-33: 113: 69.15
+	Hs
		167726 LSM2_HUMAN (1-95): 1.9e-35: 117: 91.58		LSM1_HUMAN (2-90): 3.41e-25: 93: 26.97
+	Hs
		928046 LSM2_HUMAN (1-95): 1.9e-35: 117: 91.58		RSMN_HUMAN (2-75): 3.88e-24: 93: 31.33
+	Dm
		1374114 Q9VTW6_DROME (1-95): 1.78e-35: 117: 100.00		Q9W2K2_DROME (2-90): 4.87e-25: 92.6: 28.09
+	Hs
		539197 LSM2_HUMAN (1-95): 1.9e-35: 117: 91.58		RSMB_HUMAN (2-75): 1.3e-23: 91.4: 31.33
+	Hs
		1356292 LSM2_HUMAN (1-95): 1.9e-35: 117: 91.58		LSM7_HUMAN (4-74): 1.57e-23: 87.6: 29.33
+	Hs
		912133 LSM2_HUMAN (1-95): 1.9e-35: 117: 91.58		RUXG_HUMAN (4-74): 1.42e-21: 81.8: 29.58
+	Hs
		167728 LSM4_HUMAN (1-87): 5.83e-30: 105: 31.03		LSM1_HUMAN (2-90): 3.41e-25: 93: 26.97
+	Hs
		928049 LSM4_HUMAN (1-87): 5.83e-30: 105: 31.03		RSMN_HUMAN (2-75): 3.88e-24: 93: 31.33
+	Hs
		539204 LSM4_HUMAN (1-87): 5.83e-30: 105: 31.03		RSMB_HUMAN (2-75): 1.3e-23: 91.4: 31.33
+	Sc
		746307 LSM2_YEAST (1-95): 1.08e-29: 103: 64.21		LSM1_YEAST (2-79): 9.35e-24: 90.3: 27.85
+	Hs
		1356296 LSM4_HUMAN (1-87): 5.83e-30: 105: 31.03		LSM7_HUMAN (4-74): 1.57e-23: 87.6: 29.33
+	Dm
		1368675 Q9VKW8_DROME (1-95): 3.05e-32: 111: 28.57		Q9VJI7_DROME (4-74): 1.82e-20: 80.3: 26.32
+	Sc
		746327 LSM2_YEAST (1-95): 1.08e-29: 103: 64.21		LSM7_YEAST (4-84): 3.01e-21: 82.2: 23.86
+	Sc
		746331 LSM2_YEAST (1-95): 1.08e-29: 103: 64.21		LSM3_YEAST (4-82): 1.66e-20: 79.5: 23.17
+	Sc
		746294 LSM2_YEAST (1-95): 1.08e-29: 103: 64.21		RSMB_YEAST (2-74): 2.73e-18: 76.8: 29.67
+	Sc
		746309 LSM2_YEAST (1-95): 1.08e-29: 103: 64.21		LSM8_YEAST (2-80): 5.54e-18: 73.7: 32.91
+	Hs
		68409 SMD1_HUMAN (1-95): 8.63e-28: 99.2: 28.42		RUXGL_HUMAN (4-74): 1.04e-19: 77.2: 29.58