HitPredict - High confidence protein-protein interactions

Interactor 1: PSN (O02194)
Presenilin homolog (DmPS) (EC 3.4.23.-) (dPS)
Gene: PSN

Interactor 2: PSN (O02194)
Presenilin homolog (DmPS) (EC 3.4.23.-) (dPS)
Gene: PSN

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	15220354, 11557046
Identification Methods	protein complementation assay, two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Presenilin~Presenilin
Common GO terms	GO:0000139 - Golgi membrane GO:0004175 - endopeptidase activity GO:0005634 - nucleus GO:0005743 - mitochondrial inner membrane GO:0005765 - lysosomal membrane and 24 others more... GO:0005789 - endoplasmic reticulum membrane GO:0005938 - cell cortex GO:0006508 - proteolysis GO:0006509 - membrane protein ectodomain proteolysis GO:0006816 - calcium ion transport GO:0006915 - apoptotic process GO:0007219 - Notch signaling pathway GO:0007220 - Notch receptor processing GO:0009986 - cell surface GO:0016324 - apical plasma membrane GO:0016485 - protein processing GO:0030018 - Z disc GO:0030426 - growth cone GO:0031594 - neuromuscular junction GO:0034205 - amyloid-beta formation GO:0035253 - ciliary rootlet GO:0035333 - Notch receptor processing, ligand-dependent GO:0042500 - aspartic endopeptidase activity, intramembrane cleaving GO:0043025 - neuronal cell body GO:0043066 - negative regulation of apoptotic process GO:0043198 - dendritic shaft GO:0045121 - membrane raft GO:0048471 - perinuclear region of cytoplasm GO:0070765 - gamma-secretase complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	541
Dm

1	541

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Last updated: 15 Jul 2024