Protein: HMGN2
Non-histone chromosomal protein HMG-17 (High mobility group nucleosome-binding domain-containing protein 2)

Gene: HMGN2
Organism: Homo sapiens
Interactions: 212
UniProt ID: P05204

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

137408

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

5

1

High-throughput

0.702

High

426472

H4
Histone H4

4

1

High-throughput

0.683

High

426548

H2B1H
Histone H2B type 1-H

4

20

High-throughput

0.683

High

426590

PARP2
Poly [ADP-ribose] polymerase 2

3

3

Small-scale

0.662

High

426427

H2A1
Histone H2A type 1

3

10

High-throughput

0.656

High

426466

H2B1D
Histone H2B type 1-D

3

20

High-throughput

0.640

High

426480

H31
Histone H3.1

3

7

High-throughput

0.640

High

426501

TERF2
Telomeric repeat-binding factor 2

2

2

High-throughput

0.631

High

277511

H2AY
Core histone macro-H2A.1

2

14

High-throughput

0.611

High

426486

GLGB
1,4-alpha-glucan-branching enzyme

2

0

High-throughput

0.602

High

426465

H2BFS
Histone H2B type F-S

2

20

High-throughput

0.601

High

426507

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.601

High

426512

H2B2F
Histone H2B type 2-F

2

20

High-throughput

0.601

High

426530

ASXL1
Polycomb group protein ASXL1

2

2

High-throughput

0.601

High

426488

EP300
Histone acetyltransferase p300

2

6

Small-scale

0.595

High

426526

NAA40
N-alpha-acetyltransferase 40

2

0

High-throughput

0.585

High

256734

H2B1K
Histone H2B type 1-K

2

20

High-throughput

0.584

High

426422

H2B1J
Histone H2B type 1-J

2

20

High-throughput

0.584

High

426445

H2B1O
Histone H2B type 1-O

2

20

High-throughput

0.584

High

426473

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

426502

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

2

1

High-throughput

0.584

High

426521

H32
Histone H3.2

2

7

High-throughput

0.584

High

426549

H2B1A
Histone H2B type 1-A

2

20

High-throughput

0.584

High

426565

H2B1L
Histone H2B type 1-L

2

20

High-throughput

0.584

High

426471

RL23A
Large ribosomal subunit protein uL23

2

0

High-throughput

0.576

High

426511

PDCD4
Programmed cell death protein 4

2

0

High-throughput

0.576

High

426535

KLH36
Kelch-like protein 36

2

1

High-throughput

0.574

High

424333

HMGN1
Non-histone chromosomal protein HMG-14

2

0

High-throughput

0.559

High

426449

APEX1
DNA repair nuclease/redox regulator APEX1

2

0

High-throughput

0.559

High

426432

TAU
Microtubule-associated protein tau

2

3

High-throughput

0.552

High

426443

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

352290

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.536

High

355402

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

High-throughput

0.536

High

426494

MDC1
Mediator of DNA damage checkpoint protein 1

1

3

High-throughput

0.536

High

426505

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

426534

KDM8
Bifunctional peptidase and arginyl-hydroxylase JMJD5

1

1

High-throughput

0.536

High

426561

BARD1
BRCA1-associated RING domain protein 1

1

1

High-throughput

0.536

High

426580

KMT5A
N-lysine methyltransferase KMT5A

1

2

High-throughput

0.536

High

426583

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

9

High-throughput

0.536

High

426587

H2AW
Core histone macro-H2A.2

1

14

High-throughput

0.536

High

426594

BAZ1B
Tyrosine-protein kinase BAZ1B

1

9

High-throughput

0.536

High

66035

LRIQ4
Leucine-rich repeat and IQ domain-containing protein 4

1

1

High-throughput

0.515

High

321810

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

1

High-throughput

0.515

High

336318

SVIL
Supervillin

1

1

High-throughput

0.515

High

418776

H2A1B
Histone H2A type 1-B/E

1

10

High-throughput

0.515

High

426431

H14
Histone H1.4

1

3

High-throughput

0.515

High

426437

H15
Histone H1.5

1

3

High-throughput

0.515

High

426444

ICAL
Calpastatin

1

1

High-throughput

0.515

High

426452

CAPG
Macrophage-capping protein

1

1

High-throughput

0.515

High

426484

RHG04
Rho GTPase-activating protein 4

1

1

High-throughput

0.515

High

426485

H11
Histone H1.1

1

3

High-throughput

0.515

High

426493

HNF4G
Hepatocyte nuclear factor 4-gamma

1

1

High-throughput

0.515

High

426503

RHOH
Rho-related GTP-binding protein RhoH

1

1

High-throughput

0.515

High

426506

H31T
Histone H3.1t

1

7

High-throughput

0.515

High

426520

RHG27
Rho GTPase-activating protein 27

1

2

High-throughput

0.515

High

426537

ANR31
Ankyrin repeat domain-containing protein 31

1

2

High-throughput

0.515

High

426540

SYNE1
Nesprin-1

1

1

High-throughput

0.515

High

426542

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

1

High-throughput

0.515

High

426557

H2A1H
Histone H2A type 1-H

1

10

High-throughput

0.515

High

426576

RPF2
Ribosome production factor 2 homolog

1

1

High-throughput

0.515

High

426599

SHOC2
Leucine-rich repeat protein SHOC-2

1

1

High-throughput

0.515

High

426435

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.513

High

426461

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.513

High

426538

Z280C
Zinc finger protein 280C

1

0

High-throughput

0.513

High

426544

ATRIP
ATR-interacting protein

1

0

High-throughput

0.513

High

426577

PARVB
Beta-parvin

1

0

High-throughput

0.513

High

426421

HMGN2
Non-histone chromosomal protein HMG-17

1

1

Small-scale

0.501

High

426426

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.501

High

426481

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.501

High

426513

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.501

High

426546

KAT2B
Histone acetyltransferase KAT2B

1

6

Small-scale

0.501

High

426585

HPF1
Histone PARylation factor 1

1

1

Small-scale

0.501

High

224926

TLX3
T-cell leukemia homeobox protein 3

1

0

High-throughput

0.493

High

317504

TPPP
Tubulin polymerization-promoting protein

1

0

High-throughput

0.493

High

335416

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.493

High

426433

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

0

High-throughput

0.493

High

426454

UTRN
Utrophin

1

0

High-throughput

0.493

High

426469

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.493

High

426489

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.493

High

426496

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.493

High

426504

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

0

High-throughput

0.493

High

426517

TWF2
Twinfilin-2

1

0

High-throughput

0.493

High

426539

ABCF1
ATP-binding cassette sub-family F member 1

1

0

High-throughput

0.493

High

426541

NEK11
Serine/threonine-protein kinase Nek11

1

0

High-throughput

0.493

High

426550

AIDA
Axin interactor, dorsalization-associated protein

1

0

High-throughput

0.493

High

426558

ALPK3
Alpha-protein kinase 3

1

0

High-throughput

0.493

High

426566

RHXF2
Rhox homeobox family member 2

1

0

High-throughput

0.493

High

426575

WNK1
Serine/threonine-protein kinase WNK1

1

0

High-throughput

0.493

High

426581

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.493

High

426586

OSER1
Oxidative stress-responsive serine-rich protein 1

1

0

High-throughput

0.493

High

426588

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.493

High

426598

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.493

High

426602

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.493

High

426429

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

426439

KPCA
Protein kinase C alpha type

1

0

Small-scale

0.480

High

426477

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

222633

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

259297

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

330566

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

395318

ESR1
Estrogen receptor

1

1

High-throughput

0.479

High

400109

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

426423

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.479

High

426425

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

426428

POTEI
POTE ankyrin domain family member I

1

1

High-throughput

0.479

High

426430

ARAF
Serine/threonine-protein kinase A-Raf

1

1

High-throughput

0.479

High

426434

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

426438

H12
Histone H1.2

1

3

High-throughput

0.479

High

426440

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

426450

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

426456

PRC2A
Protein PRRC2A

1

2

High-throughput

0.479

High

426457

HSP77
Putative heat shock 70 kDa protein 7

1

2

High-throughput

0.479

High

426458

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

426459

CENPA
Histone H3-like centromeric protein A

1

7

High-throughput

0.479

High

426463

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

426464

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

426483

H33
Histone H3.3

1

7

High-throughput

0.479

High

426490

IKZF1
DNA-binding protein Ikaros

1

1

High-throughput

0.479

High

426498

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

426499

BRD3
Bromodomain-containing protein 3

1

6

High-throughput

0.479

High

426510

AMOT
Angiomotin

1

1

High-throughput

0.479

High

426516

H2A2A
Histone H2A type 2-A

1

10

High-throughput

0.479

High

426519

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

426522

H2AV
Histone H2A.V

1

12

High-throughput

0.479

High

426523

ASXL2
Putative Polycomb group protein ASXL2

1

4

High-throughput

0.479

High

426527

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.479

High

426528

H2A2B
Histone H2A type 2-B

1

10

High-throughput

0.479

High

426531

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

426532

SRRM1
Serine/arginine repetitive matrix protein 1

1

2

High-throughput

0.479

High

426533

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.479

High

426547

H2A1C
Histone H2A type 1-C

1

10

High-throughput

0.479

High

426554

OPTN
Optineurin

1

2

High-throughput

0.479

High

426562

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.479

High

426563

H2A1J
Histone H2A type 1-J

1

10

High-throughput

0.479

High

426564

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.479

High

426568

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

426572

ASXL3
Putative Polycomb group protein ASXL3

1

5

High-throughput

0.479

High

426589

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

426592

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.479

High

426593

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

5

High-throughput

0.479

High

426595

IKZF3
Zinc finger protein Aiolos

1

1

High-throughput

0.479

High

426500

RABE1
Rab GTPase-binding effector protein 1

1

1

High-throughput

0.470

High

426559

STAC3
SH3 and cysteine-rich domain-containing protein 3

1

2

High-throughput

0.470

High

426596

AT7L1
Ataxin-7-like protein 1

1

2

High-throughput

0.470

High

426603

PCLO
Protein piccolo

1

1

High-throughput

0.470

High

2130

PAL4C
Peptidyl-prolyl cis-trans isomerase A-like 4C

1

0

High-throughput

0.458

High

184536

DFB4A
Defensin beta 4A

1

0

Small-scale

0.458

High

226668

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

High-throughput

0.458

High

297400

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.458

High

362583

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

370917

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

426424

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.458

High

426441

IBP3
Insulin-like growth factor-binding protein 3

1

0

Small-scale

0.458

High

426446

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

426447

CO5A3

1

0

High-throughput

0.458

High

426451

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

426453

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.458

High

426462

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

426467

RHOA
Transforming protein RhoA

1

0

High-throughput

0.458

High

426470

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

426474

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

426475

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.458

High

426476

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.458

High

426478

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

426479

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

426482

ARF1
ADP-ribosylation factor 1

1

0

High-throughput

0.458

High

426487

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.458

High

426491

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

0

High-throughput

0.458

High

426492

CYLC2
Cylicin-2

1

0

High-throughput

0.458

High

426495

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.458

High

426515

USF3
Basic helix-loop-helix domain-containing protein USF3

1

0

High-throughput

0.458

High

426524

G2E3
G2/M phase-specific E3 ubiquitin-protein ligase

1

0

High-throughput

0.458

High

426543

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

426551

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

426553

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.458

High

426569

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

426570

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

0

High-throughput

0.458

High

426571

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

426573

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

426574

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.458

High

426579

RM40
Large ribosomal subunit protein mL40

1

0

High-throughput

0.458

High

426597

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.458

High

426600

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

426601

MYH15
Myosin-15

1

0

High-throughput

0.458

High

426448

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.437

High

426497

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.437

High

426545

RND1
Rho-related GTP-binding protein Rho6

1

1

High-throughput

0.437

High

354498

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

426468

1433G
14-3-3 protein gamma

1

0

High-throughput

0.426

High

426460

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

426578

CHM1A
Charged multivesicular body protein 1a

2

0

High-throughput

0.328

High

426455

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.282

High

247069

TBCD4
TBC1 domain family member 4

1

0

High-throughput

0.269

Low

426442

ITB6
Integrin beta-6

1

0

High-throughput

0.269

Low

426508

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.269

Low

426509

FWCH1
FLYWCH-type zinc finger-containing protein 1

1

0

High-throughput

0.269

Low

426525

MON2
Protein MON2 homolog

1

0

High-throughput

0.269

Low

426529

CF337
Cilia- and flagella-associated protein 337

1

0

High-throughput

0.269

Low

426536

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.269

Low

426552

ASTRA
Protein Aster-A

1

0

High-throughput

0.269

Low

426556

MEG10
Multiple epidermal growth factor-like domains protein 10

1

0

High-throughput

0.269

Low

426560

KCNKG
Potassium channel subfamily K member 16

1

0

High-throughput

0.269

Low

426567

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.269

Low

426582

MXRA5
Matrix-remodeling-associated protein 5

1

0

High-throughput

0.269

Low

426591

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.269

Low

156839

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

276940

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

High-throughput

0.249

Low

426436

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.249

Low

426514

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

426518

DTHD1
Death domain-containing protein 1

1

0

High-throughput

0.249

Low

426555

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.249

Low

426584

CCM2L
Cerebral cavernous malformations 2 protein-like

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025