Interactor 1: PSN (O02194)
Presenilin homolog (DmPS) (EC 3.4.23.-) (dPS)
Gene: PSN

Interactor 2: APH1 (Q9VQG2)
Gamma-secretase subunit Aph-1 (Presenilin-stabilization factor)
Gene: aph-1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 20421416, 15644323
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Aph-1~Presenilin
Common GO terms GO:0006509 - membrane protein ectodomain proteolysis
GO:0007219 - Notch signaling pathway
GO:0007220 - Notch receptor processing
GO:0016485 - protein processing
GO:0034205 - amyloid-beta formation
and 2 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 541
Dm

1 238
+ Rn
+ Hs
+ Mm
+ Mm
+ Hs
+ At
+ Mm
+ Hs
+ Hs
+ At

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Last updated: 15 Jul 2024