HitPredict

Interactor 1: RAD50 (Q9W252)
DNA repair protein RAD50 (EC 3.6.-.-)
Gene: RAD50

Interactor 2: Q9XYZ4 (Q9XYZ4)
Double-strand break repair protein
Gene: mre11

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.850

Property	Details
Experiments	19520832, 25588834, 15710747
Identification Methods	affinity chromatography technology, two hybrid, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	AAA_23~Metallophos, AAA_23~Mre11_DNA_bind, Metallophos~SbcC_Walker_B
Common GO terms	GO:0000723 - telomere maintenance GO:0030870 - Mre11 complex GO:0051276 - chromosome organization
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1318 Dm			1 620
+	Hs
		837057 RAD50_HUMAN (1-1305): 2.36e-96: 339: 27.13		MRE11_HUMAN (4-611): 0: 788: 39.84
+	Mm
		936706 RAD50_MOUSE (1-1315): 6.17e-97: 341: 26.93		MRE11_MOUSE (4-611): 0: 775: 40.32
+	Hs
		837017 SMC1A_HUMAN (1-1291): 4.93e-66: 247: 12.21		MRE11_HUMAN (4-611): 0: 788: 39.84
+	At
		1352506 RAD50_ARATH (1-1308): 5.98e-77: 282: 23.77		MRE11_ARATH (7-610): 0: 690: 36.73
+	Sc
		521122 RAD50_YEAST (1-1309): 5.14e-71: 263: 24.19		MRE11_YEAST (11-617): 0: 646: 33.49
+	Ce
		218193 RAD50_CAEEL (1-1301): 4.51e-71: 263: 20.55		MRE11_CAEEL (3-522): 0: 589: 35.38