HitPredict

Interactor 1: Q9W325 (Q9W325)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
Gene: Hecw

Interactor 2: Q9W418 (Q9W418)
GH17761p (Ubiquitin-5E, isoform A) (Ubiquitin-5E, isoform B)
Gene: Ubi-p5E

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 436 Dm			1 534
+	Dm
		89879 D5SHR3_DROME (16-436): 0: 539: 99.76		UBIQP_DROME (1-458): 0: 566: 99.78
+	Hs
		475470 NEDD4_HUMAN (2-434): 0: 579: 44.60		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		476229 NED4L_HUMAN (2-434): 0: 570: 43.45		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		476205 ITCH_HUMAN (6-436): 0: 569: 44.80		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		125113 WWP2_HUMAN (7-436): 0: 559: 43.65		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		476350 WWP1_HUMAN (6-436): 0: 557: 44.04		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		476403 SMUF2_HUMAN (2-436): 0: 539: 39.53		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		475963 HECW1_HUMAN (13-436): 3.3e-177: 538: 71.53		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		475984 HUWE1_HUMAN (1-435): 1.93e-171: 535: 36.55		UBC_HUMAN (1-153): 1.26e-52: 191: 99.35
+	Hs
		125347 WWP2_HUMAN (7-436): 0: 559: 43.65		RS27A_HUMAN (381-458): 1.34e-41: 148: 97.44
+	Hs
		924156 WWP1_HUMAN (6-436): 0: 557: 44.04		RS27A_HUMAN (381-458): 1.34e-41: 148: 97.44
+	Rn
		1140970 Q5YB86_RAT (6-436): 0: 566: 44.80		UBC_RAT (1-108): 3.8e-30: 127: 90.74
+	Hs
		474953 NEDD4_HUMAN (2-434): 0: 579: 44.60		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Hs
		475140 ITCH_HUMAN (6-436): 0: 569: 44.80		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Hs
		125112 WWP2_HUMAN (7-436): 0: 559: 43.65		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Mm
		476858 HUWE1_MOUSE (1-435): 4.09e-171: 534: 36.55		UBC_MOUSE (1-108): 3.81e-30: 127: 90.74
+	Hs
		397834 NEDD4_HUMAN (2-434): 0: 579: 44.60		ISG15_HUMAN (307-456): 2.08e-17: 81.6: 32.68
+	Sc
		477293 RSP5_YEAST (4-436): 0: 544: 45.85		UBI4P_YEAST (1-77): 3.08e-23: 103: 94.81
+	Hs
		475196 SMUF2_HUMAN (2-436): 0: 539: 39.53		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70
+	Hs
		475080 HUWE1_HUMAN (1-435): 1.93e-171: 535: 36.55		UBB_HUMAN (1-77): 5.2e-26: 107: 98.70