HitPredict

Interactor 1: X5D985 (X5D985)
Neuronal PAS domain protein 3 isoform F
Gene: NPAS3

Interactor 2: X5DP31 (X5DP31)
Aryl-hydrocarbon receptor nuclear translocator 2 isoform E
Gene: ARNT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	24722188
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS~PAS_3, PAS_11~PAS_3
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 901 Hs			1 660
+	Hs
		1220559 NPAS3_HUMAN (1-901): 0: 918: 96.36		X5DP31_HUMAN (1-660): 0: 684: 100.00
+	Hs
		1335644 X5D985_HUMAN (1-901): 0: 929: 100.00		ARNT2_HUMAN (1-658): 0: 631: 89.88
+	Hs
		1378460 X5D985_HUMAN (1-901): 0: 929: 100.00		X5D7T2_HUMAN (1-658): 0: 628: 89.73
+	Hs
		1220557 NPAS3_HUMAN (1-901): 0: 918: 96.36		ARNT2_HUMAN (1-658): 0: 631: 89.88
+	Hs
		1335647 X5DR67_HUMAN (1-901): 0: 918: 97.39		ARNT2_HUMAN (1-658): 0: 631: 89.88
+	Hs
		1220558 NPAS3_HUMAN (1-901): 0: 918: 96.36		X5D7T2_HUMAN (1-658): 0: 628: 89.73
+	Hs
		1378461 X5DR67_HUMAN (1-901): 0: 918: 97.39		X5D7T2_HUMAN (1-658): 0: 628: 89.73
+	Hs
		649132 NPAS3_HUMAN (1-901): 0: 918: 96.36		ARNT_HUMAN (4-658): 0: 545: 52.40
+	Mm
		101520 F8VQB2_MOUSE (9-901): 0: 888: 93.73		ARNT_MOUSE (4-658): 0: 542: 53.35
+	Hs
		1306541 EPAS1_HUMAN (7-738): 2.9e-140: 440: 22.67		ARNT2_HUMAN (1-658): 0: 631: 89.88
+	Hs
		649150 EPAS1_HUMAN (7-738): 2.9e-140: 440: 22.67		ARNT_HUMAN (4-658): 0: 545: 52.40
+	Hs
		126166 EPAS1_HUMAN (7-738): 2.9e-140: 440: 22.67		BMAL1_HUMAN (15-593): 2.35e-166: 492: 30.31
+	Hs
		1264408 EPAS1_HUMAN (7-738): 2.9e-140: 440: 22.67		BMAL2_HUMAN (48-551): 2.11e-146: 441: 32.35
+	Hs
		1306527 EPAS1_HUMAN (7-738): 2.9e-140: 440: 22.67		EPAS1_HUMAN (50-658): 2.53e-127: 398: 20.32
+	Hs
		1085655 EPAS1_HUMAN (7-738): 2.9e-140: 440: 22.67		HIF1A_HUMAN (48-604): 2.8e-127: 397: 20.46
+	Hs
		1085690 ARNT2_HUMAN (8-690): 7.63e-138: 429: 17.56		HIF1A_HUMAN (48-604): 2.8e-127: 397: 20.46
+	Hs
		1050587 ARNT2_HUMAN (8-690): 7.63e-138: 429: 17.56		SIM2_HUMAN (65-650): 9.12e-129: 396: 19.29
+	Hs
		1306557 EPAS1_HUMAN (7-738): 2.9e-140: 440: 22.67		HIF3A_HUMAN (50-647): 5.8e-117: 366: 18.70
+	Hs
		946354 ARNT2_HUMAN (8-690): 7.63e-138: 429: 17.56		SIM1_HUMAN (65-535): 3.34e-111: 353: 21.04
+	Hs
		728962 ARNT2_HUMAN (8-690): 7.63e-138: 429: 17.56		AHR_HUMAN (32-589): 2.27e-105: 340: 15.46